Sugammadex

Sugammadex

Trade names	Bridion
Clinical data
Uses	Reversal of neuromuscular blockade from rocuronium and vecuronium
Contraindications	Renal impairment
Routes of administration	Intravenous
Dosage	Based upon response to train-of-four stimulation: 2+ twitches: 2 mg/kg 1-2 posttetanic twitches: 4 mg/kg Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg
Pharmacodynamics
Mechanism of action	Encapsulation of rocuronium or vecuronium
Adverse effects	Bradycardia, may interfere with hormonal contraceptives
Pharmacokinetics
Physical and chemical data
Formula	C72H112O48S8
Molar mass	2002.12 g/mol

Sugammadex is used to reverse neuromuscular blockade from rocuronium and vecuronium.

Uses

If a patient requires reparaylsis after administration of sugammadex (up to 4 mg/kg), rocuronium or vecuronium can be re-administered after a minimum waiting time.

Drug and dose to be administered	Minimum waiting time
Rocuronium 1.2 mg/kg	5 minutes
Rocuronium 0.6 mg/kg or vecuronium 0.1 mg/kg	4 hours