Rocuronium
Trade names

Zemuron

Rocuronium.svg
Clinical data
Drug class

Neuromuscular blocker

Routes of administration

Intravenous

Dosage
Pharmacodynamics
Mechanism of action

Nicotinic acetylcholine antagonism

Pharmacokinetics
Onset of action

Standard Intubating Dose: 1.5 minutes Rapid Sequence Induction Dose: 90 seconds

Duration of action

35-75 minutes (Dose Dependent)

Physical and chemical data
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Rocuronium is an intermediate duration non-depolarizing muscle relaxant.

Uses

Contraindications

Absolute contraindications

Precautions

Pharmacology

Pharmacodynamics

Mechanism of action

Rocuronium is a competitive nicotinic acetylcholine receptor antagonist. By blocking acetylcholine from binding it inhibits depolarization.[1]

Adverse effects

Pharmacokinetics

Onset for 0.6 - 0.8 mg/kg Dose: 1.5 minutes

Onset for 0.9 - 1.2 mg/kg Dose: 60 - 90 seconds[1]

Chemistry and formulation

Monoquaternary steroid non-depolarizing muscle relaxant.[1]

History

References

  1. 1.0 1.1 1.2 Butterworth IV, John F.; Mackey, David C.; Wasnick, John D. (2022), "Neuromuscular Blocking Agents", Morgan & Mikhail’s Clinical Anesthesiology (7 ed.), New York, NY: McGraw-Hill Education, retrieved 2022-12-22