Difference between revisions of "Sugammadex"
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==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ||
If a patient requires reparaylsis after administration of sugammadex (up to 4 mg/kg), rocuronium or vecuronium can be re-administered after a minimum waiting time.<ref>{{Cite web|last=|first=|date=|title=BRIDION® (sugammadex) Injection Drug Label (FDA)|url=https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022225lbl.pdf|url-status=live|archive-url=|archive-date=|access-date=|website=}}</ref> | |||
{| class="wikitable" | |||
|+ | |||
!Drug and dose to be administered | |||
!Minimum waiting time | |||
|- | |||
|Rocuronium 1.2 mg/kg | |||
|5 minutes | |||
|- | |||
|Rocuronium 0.6 mg/kg or | |||
vecuronium 0.1 mg/kg | |||
|4 hours | |||
|} | |||
==Contraindications<!-- List contraindications and precautions for use of the drug. -->== | ==Contraindications<!-- List contraindications and precautions for use of the drug. -->== | ||
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==References== | ==References== | ||
<references /> | |||
Revision as of 05:11, 18 February 2021
Sugammadex
| Trade names |
Bridion |
|---|---|
 | |
| Clinical data | |
| Uses |
Reversal of neuromuscular blockade from rocuronium and vecuronium |
| Contraindications |
Renal impairment |
| Routes of administration |
Intravenous |
| Dosage |
Based upon response to train-of-four stimulation:
|
| Pharmacodynamics | |
| Mechanism of action |
Encapsulation of rocuronium or vecuronium |
| Adverse effects |
Bradycardia, may interfere with hormonal contraceptives |
| Pharmacokinetics | |
| Physical and chemical data | |
| Formula |
C72H112O48S8 |
| Molar mass |
2002.12 g/mol |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Sugammadex is used to reverse neuromuscular blockade from rocuronium and vecuronium.
Uses
If a patient requires reparaylsis after administration of sugammadex (up to 4 mg/kg), rocuronium or vecuronium can be re-administered after a minimum waiting time.[1]
| Drug and dose to be administered | Minimum waiting time |
|---|---|
| Rocuronium 1.2 mg/kg | 5 minutes |
| Rocuronium 0.6 mg/kg or
vecuronium 0.1 mg/kg |
4 hours |
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
Top contributors: Chris Rishel and Tymoteusz Kajstura