Difference between revisions of "Factor V Leiden"
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}} | }}Factor V Leiden is a mutated form of clotting factor V resulting in hypercoagulability. | ||
==Anesthetic implications<!-- Briefly summarize the anesthetic implications of this comorbidity. -->== | ==Anesthetic implications<!-- Briefly summarize the anesthetic implications of this comorbidity. -->== | ||
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==Pathophysiology<!-- Describe the pathophysiology of this comorbidity. Add subsections as needed. -->== | ==Pathophysiology<!-- Describe the pathophysiology of this comorbidity. Add subsections as needed. -->== | ||
In a normal patient, protein C is an anticoagulant protein which binds to factor V to inhibit its function. The Factor V Leiden mutation results in an inability of Protein C to bind to factor V, thus resulting in hypercoagulability. | |||
==Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. -->== | ==Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. -->== | ||
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===Prognosis<!-- Describe the prognosis of this comorbidity -->=== | ===Prognosis<!-- Describe the prognosis of this comorbidity -->=== | ||
Factor V Leiden does not result in decreased life expectancy despite increased risk for DVT. | |||
==Epidemiology<!-- Describe the epidemiology of this comorbidity -->== | ==Epidemiology<!-- Describe the epidemiology of this comorbidity -->== | ||
Most common in ethnic Europeans. Named after the Dutch city of Leiden. | |||
==References== | ==References== | ||
[[Category:Comorbidities]] | [[Category:Comorbidities]] | ||
Latest revision as of 11:18, 16 December 2021
Factor V Leiden
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Factor V Leiden is a mutated form of clotting factor V resulting in hypercoagulability.
Anesthetic implications
Preoperative optimization
Intraoperative management
Postoperative management
Related surgical procedures
Pathophysiology
In a normal patient, protein C is an anticoagulant protein which binds to factor V to inhibit its function. The Factor V Leiden mutation results in an inability of Protein C to bind to factor V, thus resulting in hypercoagulability.
Signs and symptoms
Diagnosis
Treatment
Medication
Surgery
Prognosis
Factor V Leiden does not result in decreased life expectancy despite increased risk for DVT.
Epidemiology
Most common in ethnic Europeans. Named after the Dutch city of Leiden.