Factor V Leiden

Factor V Leiden

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Factor V Leiden is a mutated form of clotting factor V resulting in hypercoagulability.

Pathophysiology

In a normal patient, protein C is an anticoagulant protein which binds to factor V to inhibit its function. The Factor V Leiden mutation results in an inability of Protein C to bind to factor V, thus resulting in hypercoagulability.

Treatment

Prognosis

Factor V Leiden does not result in decreased life expectancy despite increased risk for DVT.

Epidemiology

Most common in ethnic Europeans. Named after the Dutch city of Leiden.