Factor V Leiden
Anesthetic relevance
Anesthetic management {{{anesthetic_management}}}
Specialty
Signs and symptoms
Diagnosis
Treatment

Factor V Leiden is a mutated form of clotting factor V resulting in hypercoagulability.

Anesthetic implications

Preoperative optimization

Intraoperative management

Postoperative management

Related surgical procedures

Pathophysiology

In a normal patient, protein C is an anticoagulant protein which binds to factor V to inhibit its function. The Factor V Leiden mutation results in an inability of Protein C to bind to factor V, thus resulting in hypercoagulability.

Signs and symptoms

Diagnosis

Treatment

Medication

Surgery

Prognosis

Factor V Leiden does not result in decreased life expectancy despite increased risk for DVT.

Epidemiology

Most common in ethnic Europeans. Named after the Dutch city of Leiden.

References