Difference between revisions of "Sugammadex"
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Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg | Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg | ||
|halflife_elimination=|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>|image_file=Sugammadex.svg|protein_binding=|clearance=|time_onset=|halflife_redistribution=|metabolism=|duration=|adverse_effects=Bradycardia, may interfere with hormonal contraceptives|mechanism=Encapsulation of rocuronium or vecuronium|molar_mass=2002.12 g/mol}} | |halflife_elimination=|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>|image_file=Sugammadex.svg|protein_binding=|clearance=|time_onset=|halflife_redistribution=|metabolism=|duration=|adverse_effects=Bradycardia, may interfere with hormonal contraceptives|mechanism=Encapsulation of rocuronium or vecuronium|molar_mass=2002.12 g/mol}} | ||
'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]]. | '''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]]. | ||
Revision as of 07:00, 21 February 2021
Sugammadex
| Trade names |
Bridion |
|---|---|
 | |
| Clinical data | |
| Uses |
Reversal of neuromuscular blockade from rocuronium and vecuronium |
| Contraindications |
Renal impairment |
| Routes of administration |
Intravenous |
| Dosage |
Based upon response to train-of-four stimulation:
Reversal immediately after administration of rocuronium 1.2 mg/kg: 16 mg/kg |
| Pharmacodynamics | |
| Mechanism of action |
Encapsulation of rocuronium or vecuronium |
| Adverse effects |
Bradycardia, may interfere with hormonal contraceptives |
| Pharmacokinetics | |
| Physical and chemical data | |
| Formula |
C72H112O48S8 |
| Molar mass |
2002.12 g/mol |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Sugammadex is used to reverse neuromuscular blockade from rocuronium and vecuronium.
Uses
If a patient requires reparaylsis after administration of sugammadex (up to 4 mg/kg), rocuronium or vecuronium can be re-administered after a minimum waiting time.[1]
| Drug and dose to be administered | Minimum waiting time |
|---|---|
| Rocuronium 1.2 mg/kg | 5 minutes |
| Rocuronium 0.6 mg/kg or
vecuronium 0.1 mg/kg |
4 hours |
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
Top contributors: Chris Rishel and Tymoteusz Kajstura