Difference between revisions of "Sugammadex"
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{{Infobox drug reference | {{Infobox drug reference | ||
| trade_names =Bridion | | trade_names = Bridion | ||
| drug_class = | | drug_class = | ||
| drug_class_color =neuromuscular_blocker_reversal | | drug_class_color = neuromuscular_blocker_reversal | ||
| uses =Reversal of neuromuscular blockade from [[Rocuronium|rocuronium]] and [[Vecuronium|vecuronium]] | | uses = Reversal of neuromuscular blockade from [[Rocuronium|rocuronium]] and [[Vecuronium|vecuronium]] | ||
| contraindications =Renal impairment | | contraindications = Renal impairment | ||
| routes =Intravenous | | routes = Intravenous | ||
| dosage = | | dosage = | ||
| halflife_elimination = | |||
| formula = C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub> | |||
| image_file = Sugammadex.svg | |||
| protein_binding = | |||
| clearance = | |||
|halflife_elimination=|formula=C<sub>72</sub>H<sub>112</sub>O<sub>48</sub>S<sub>8</sub>|image_file=Sugammadex.svg|protein_binding=|clearance=|time_onset=|halflife_redistribution=|metabolism=|duration=|adverse_effects=Bradycardia, may interfere with hormonal contraceptives|mechanism=Encapsulation of rocuronium or vecuronium|molar_mass=2002.12 g/mol}} | | time_onset = | ||
| halflife_redistribution = | |||
| metabolism = | |||
| duration = | |||
| adverse_effects = Bradycardia, may interfere with hormonal contraceptives | |||
| dosage_calculation = sugammadex | |||
| mechanism = Encapsulation of rocuronium or vecuronium | |||
| molar_mass = 2002.12 g/mol | |||
}} | |||
'''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]]. | '''Sugammadex''' is used to reverse neuromuscular blockade from [[rocuronium]] and [[vecuronium]]. | ||
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===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->=== | ===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->=== | ||
* Previous anaphylactic reaction to sugammadex | |||
===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->=== | ===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->=== | ||
* Sugammadex can also bind steroid-structured molecules such as estrogen and tamoxifen. Consideration to using other agents to reverse NMB should be given to those patients on tamoxifen or toremifene for breast cancer. Female patients of child-bearing age on oral birth control should be advised of the potential of a short-term decrease in the efficacy of this method of birth control following reversal with sugammadex. | |||
* Renal disease is a relative contraindication to the use of sugammadex as it is mainly renally cleared. With decreased renal clearance, the drug will stay in the body longer and the safety profile of this kind of drug exposure has not been well studied. | |||
==Pharmacology== | ==Pharmacology== | ||
Latest revision as of 23:34, 29 March 2022
Sugammadex
| Trade names |
Bridion |
|---|---|
 | |
| Clinical data | |
| Uses |
Reversal of neuromuscular blockade from rocuronium and vecuronium |
| Contraindications |
Renal impairment |
| Routes of administration |
Intravenous |
| Dosage | |
| Pharmacodynamics | |
| Mechanism of action |
Encapsulation of rocuronium or vecuronium |
| Adverse effects |
Bradycardia, may interfere with hormonal contraceptives |
| Pharmacokinetics | |
| Physical and chemical data | |
| Formula |
C72H112O48S8 |
| Molar mass |
2002.12 g/mol |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Sugammadex is used to reverse neuromuscular blockade from rocuronium and vecuronium.
Uses
If a patient requires reparaylsis after administration of sugammadex (up to 4 mg/kg), rocuronium or vecuronium can be re-administered after a minimum waiting time.[1]
| Drug and dose to be administered | Minimum waiting time |
|---|---|
| Rocuronium 1.2 mg/kg | 5 minutes |
| Rocuronium 0.6 mg/kg or
vecuronium 0.1 mg/kg |
4 hours |
Contraindications
Absolute contraindications
- Previous anaphylactic reaction to sugammadex
Precautions
- Sugammadex can also bind steroid-structured molecules such as estrogen and tamoxifen. Consideration to using other agents to reverse NMB should be given to those patients on tamoxifen or toremifene for breast cancer. Female patients of child-bearing age on oral birth control should be advised of the potential of a short-term decrease in the efficacy of this method of birth control following reversal with sugammadex.
- Renal disease is a relative contraindication to the use of sugammadex as it is mainly renally cleared. With decreased renal clearance, the drug will stay in the body longer and the safety profile of this kind of drug exposure has not been well studied.
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
Top contributors: Chris Rishel and Tymoteusz Kajstura