Tranexamic acid
Trade names

Lysteda, Cyklokapron

Clinical data
Drug class

Antifibrinolytic

Uses

Reduction of blood loss

Routes of administration

Intravenous

Pharmacodynamics
Pharmacokinetics
Physical and chemical data
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Tranexamic acid (TXA) is an antifibrinolytic drug used to prevent or treat blood loss from surgery and trauma.

Uses

Contraindications

Absolute contraindications

  • Hypersensitivity to TXA
  • Coronary or vascular stent placed within the past 6 months (may be extended to one year if appropriate)
  • DVT, PE, MI or ischemic stroke within the past 6 months (may be extended to one year if appropriate)
  • Subarachnoid hemorrhage
  • Retinal vein or artery occlusion
  • Active intravascular clotting
  • Concomitant use of clotting factor concentrates or anti-inhibitor coagulant concentrates
  • History of seizure disorder, or elevated seizure risk

Precautions

  • Bleeding disorders or hypercoagulable state/disorders
  • Reduce dose in renal insufficiency (see package insert for recommendations)

Pharmacology

Pharmacodynamics

Mechanism of action

Adverse effects

Pharmacokinetics

Chemistry and formulation

History

References