Tranexamic acid
Trade names Lysteda, Cyklokapron
Clinical data
Drug class Antifibrinolytic
Uses Reduction of blood loss
Routes of administration Intravenous
Pharmacodynamics
Pharmacokinetics
Physical and chemical data


Tranexamic acid (TXA) is an antifibrinolytic drug used to prevent or treat blood loss from surgery and trauma.

Uses

Contraindications

Absolute contraindications

  • Hypersensitivity to TXA
  • Coronary or vascular stent placed within the past 6 months (may be extended to one year if appropriate)
  • DVT, PE, MI or ischemic stroke within the past 6 months (may be extended to one year if appropriate)
  • Subarachnoid hemorrhage
  • Retinal vein or artery occlusion
  • Active intravascular clotting
  • Concomitant use of clotting factor concentrates or anti-inhibitor coagulant concentrates
  • History of seizure disorder, or elevated seizure risk

Precautions

  • Bleeding disorders or hypercoagulable state/disorders
  • Reduce dose in renal insufficiency (see package insert for recommendations)

Pharmacology

Pharmacodynamics

Mechanism of action

Adverse effects

Pharmacokinetics

Chemistry and formulation

History

References