Tranexamic acid

Tranexamic acid

Trade names	Lysteda, Cyklokapron
Clinical data
Drug class	Antifibrinolytic
Uses	Reduction of blood loss
Routes of administration	Intravenous
Pharmacodynamics
Pharmacokinetics
Physical and chemical data
Article quality
Editor rating	Unrated
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Tranexamic acid (TXA) is an antifibrinolytic drug used to prevent or treat blood loss from surgery and trauma.

Contraindications

Absolute contraindications

• Hypersensitivity to TXA
• Coronary or vascular stent placed within the past 6 months (may be extended to one year if appropriate)
• DVT, PE, MI or ischemic stroke within the past 6 months (may be extended to one year if appropriate)
• Subarachnoid hemorrhage
• Retinal vein or artery occlusion
• Active intravascular clotting
• Concomitant use of clotting factor concentrates or anti-inhibitor coagulant concentrates
• History of seizure disorder, or elevated seizure risk

Precautions

• Bleeding disorders or hypercoagulable state/disorders
• Reduce dose in renal insufficiency (see package insert for recommendations)