Naloxone

From WikiAnesthesia
Naloxone
Trade names Narcan
Naloxone.svg
Clinical data
Uses Reversal of opioid agonism
Routes of administration Intramuscular, Intranasal, Intravenous
Dosage 0.04-0.4 mg IV q2-3min prn
Pharmacodynamics
Mechanism of action Opioid-receptor antagonism
Adverse effects Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema
Pharmacokinetics
Onset of action 1-2 minutes (IV)
2-5 minutes (IM)
Duration of action 30-60 minutes
Metabolism Hepatic
Elimination half-life 1-1.5 hours
Physical and chemical data
Formula C19H21NO4
Molar mass 327.380 g/mol


Naloxone is an opioid-receptor antagonist which is used for the reversal of opioid overdose.

Uses

Contraindications

Absolute contraindications

Precautions

Pharmacology

Pharmacodynamics

Mechanism of action

Adverse effects

Pharmacokinetics

Chemistry and formulation

History

References