Actiq, Duragesic, Sublimaze
|Routes of administration||
Buccal, Epidural, Intrathecal, Intravenous, Transdermal
|Mechanism of action||
|Onset of action||
|Duration of action||
6 minutes (initial) 1 hour (slow)
|Physical and chemical data|
Fentanyl is a synthetic, lipophilic phenylpiperidine opioid agonist used for analgesia. It is highly lipophilic leading to fast passage across the blood-brain barrier with a 6.8 minute onset time. Fentanyl will also rapidly redistribute to adipose and fatty tissue leading to a short duration of action.
- IV, IM, transdermal, intranasal, intrathecal, epidural, buccal.
Mechanism of action
- µ-selective opioid receptor
- Low affinity: delta & kappa opioid receptors
- Context Sensitive Half Time
- Infusion or repeated doses lead to prolong duration of action as drug redistributes back from tissue to plasma.
Chemistry and formulation
- Comer SD, Cahill CM. Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment. Neurosci Biobehav Rev. 2019 Nov;106:49-57.