|Routes of administration||
IV, IM, IN
|Mechanism of action||
|Physical and chemical data|
Dexmedetomidine is an alpha-2 agonist that has been shown to have analgesic, anxiolytic, and sedative properties.
ICU, intra-operative, and procedural sedation without respiratory depression or amnestic properties. May decrease opioid requirement, more so due to sedating rather than analgesic effects.
Should be used with caution with any drugs that lower heart rate or cause hypotension as it may contribute to these hemodynamic changes.
Mechanism of action
Central α-2 agonist with a 1600:1 affinity for α-2 receptors over α-1 receptors.
Risk of hypotension and bradycardia, in a dose-dependent manner. Night terrors and transient behavioral effects in children have been reported when used for pre-anesthetic sedation, due to calming effects without amnestic properties.