Bupivacaine
Trade names Marcaine
Clinical data
Drug class Local Anesthetic
Uses Regional anesthesia, neuraxial anesthesia
Contraindications Allergy (rare), bier block (due to risk of tourniquet failure and systemic drug absorption causing cardiac arrest)
Routes of administration Intrathecal, epidural, peripheral nerve block, local infiltration
Dosage Maximum dose: 2-2.5mg/kg, not to exceed 175mg per dose or 400mg/24h Spinal anesthesia: commonly 7.5-12mg of 0.75% bupivacaine for C-section under spinal
Pharmacodynamics
Mechanism of action Sodium channel blockade
Adverse effects Cardiotoxicity, LAST
Pharmacokinetics
Onset of action Within 15 mins
Duration of action 2-8h
Metabolism Liver
Elimination half-life approx 3h
Protein binding 95%
Physical and chemical data


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Uses

Contraindications

Absolute contraindications

Precautions

Pharmacology

Pharmacodynamics

Mechanism of action

Adverse effects

Pharmacokinetics

Chemistry and formulation

History

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