Rocuronium
From WikiAnesthesia
Revision as of 12:56, 22 December 2022 by Sydney Caley (talk | contribs) (Added basic information on rocuronium mechanism of action and dosing.)
Rocuronium
| Trade names |
Zemuron |
|---|---|
 | |
| Clinical data | |
| Drug class |
Neuromuscular blocker |
| Routes of administration |
Intravenous |
| Dosage |
Intravenous - Standard Intubation Dose: 0.6 mg/kg - Rapid Sequence Intubation Dose: 1.2 mg/kg - Defasciculating Dose: 0.1 mg/kg |
| Dosage | |
| Pharmacodynamics | |
| Mechanism of action |
Nicotinic acetylcholine antagonism |
| Pharmacokinetics | |
| Onset of action |
Standard Intubating Dose: 1.5 minutes Rapid Sequence Induction Dose: 90 seconds |
| Duration of action |
35-75 minutes (Dose Dependent) |
| Physical and chemical data | |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Rocuronium is an intermediate duration non-depolarizing muscle relaxant.
Uses
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Rocuronium is a competitive nicotinic acetylcholine receptor antagonist. By blocking acetylcholine from binding it inhibits depolarization.[1]
Adverse effects
Pharmacokinetics
Onset for 0.6 - 0.8 mg/kg Dose: 1.5 minutes
Onset for 0.9 - 1.2 mg/kg Dose: 60 - 90 seconds[1]
Chemistry and formulation
Monoquaternary steroid non-depolarizing muscle relaxant.[1]
History
References
- ↑ 1.0 1.1 1.2 Butterworth IV, John F.; Mackey, David C.; Wasnick, John D. (2022), "Neuromuscular Blocking Agents", Morgan & Mikhail’s Clinical Anesthesiology (7 ed.), New York, NY: McGraw-Hill Education, retrieved 2022-12-22
Top contributors: Chris Rishel and Sydney Caley