Difference between revisions of "Rocuronium"
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Chris Rishel (talk | contribs) m (Added embedded dosage calculation) |
Sydney Caley (talk | contribs) (Added basic information on rocuronium mechanism of action and dosing.) |
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| contraindications = | | contraindications = | ||
| routes = Intravenous | | routes = Intravenous | ||
| dosage = | | dosage = Intravenous | ||
- Standard Intubation Dose: 0.6 mg/kg | |||
- Rapid Sequence Intubation Dose: 1.2 mg/kg | |||
- Defasciculating Dose: 0.1 mg/kg | |||
| halflife_redistribution = | | halflife_redistribution = | ||
| protein_binding = | | protein_binding = | ||
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| adverse_effects = | | adverse_effects = | ||
| metabolism = | | metabolism = | ||
| duration = | | duration = 35-75 minutes (Dose Dependent) | ||
| time_onset = | | time_onset = Standard Intubating Dose: 1.5 minutes | ||
Rapid Sequence Induction Dose: 90 seconds | |||
| dosage_calculation = rocuronium | | dosage_calculation = rocuronium | ||
| mechanism = Nicotinic acetylcholine antagonism | | mechanism = Nicotinic acetylcholine antagonism | ||
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}} | }} | ||
Rocuronium is an intermediate duration non-depolarizing muscle relaxant. | |||
==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ||
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====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->==== | ====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->==== | ||
Rocuronium is a competitive nicotinic acetylcholine receptor antagonist. By blocking acetylcholine from binding it inhibits depolarization.<ref name=":0">{{Citation|last=Butterworth IV|first=John F.|title=Neuromuscular Blocking Agents|date=2022|url=http://accessmedicine.mhmedical.com/content.aspx?aid=1190604416|work=Morgan & Mikhail’s Clinical Anesthesiology|edition=7|place=New York, NY|publisher=McGraw-Hill Education|access-date=2022-12-22|last2=Mackey|first2=David C.|last3=Wasnick|first3=John D.}}</ref> | |||
====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ||
===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->=== | ===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->=== | ||
Onset for 0.6 - 0.8 mg/kg Dose: 1.5 minutes | |||
Onset for 0.9 - 1.2 mg/kg Dose: 60 - 90 seconds<ref name=":0" /> | |||
==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->== | ==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->== | ||
Monoquaternary steroid non-depolarizing muscle relaxant.<ref name=":0" /> | |||
==History<!-- Describe the historical development of the drug. -->== | ==History<!-- Describe the historical development of the drug. -->== | ||
Revision as of 12:56, 22 December 2022
Rocuronium
| Trade names |
Zemuron |
|---|---|
 | |
| Clinical data | |
| Drug class |
Neuromuscular blocker |
| Routes of administration |
Intravenous |
| Dosage |
Intravenous - Standard Intubation Dose: 0.6 mg/kg - Rapid Sequence Intubation Dose: 1.2 mg/kg - Defasciculating Dose: 0.1 mg/kg |
| Dosage | |
| Pharmacodynamics | |
| Mechanism of action |
Nicotinic acetylcholine antagonism |
| Pharmacokinetics | |
| Onset of action |
Standard Intubating Dose: 1.5 minutes Rapid Sequence Induction Dose: 90 seconds |
| Duration of action |
35-75 minutes (Dose Dependent) |
| Physical and chemical data | |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Rocuronium is an intermediate duration non-depolarizing muscle relaxant.
Uses
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Rocuronium is a competitive nicotinic acetylcholine receptor antagonist. By blocking acetylcholine from binding it inhibits depolarization.[1]
Adverse effects
Pharmacokinetics
Onset for 0.6 - 0.8 mg/kg Dose: 1.5 minutes
Onset for 0.9 - 1.2 mg/kg Dose: 60 - 90 seconds[1]
Chemistry and formulation
Monoquaternary steroid non-depolarizing muscle relaxant.[1]
History
References
- ↑ 1.0 1.1 1.2 Butterworth IV, John F.; Mackey, David C.; Wasnick, John D. (2022), "Neuromuscular Blocking Agents", Morgan & Mikhail’s Clinical Anesthesiology (7 ed.), New York, NY: McGraw-Hill Education, retrieved 2022-12-22
Top contributors: Chris Rishel and Sydney Caley