Naloxone
Trade names

Narcan

Naloxone.svg
Clinical data
Uses

Reversal of opioid agonism

Routes of administration

Intramuscular, Intranasal, Intravenous

Dosage

0.04-0.4 mg IV q2-3min prn

Pharmacodynamics
Mechanism of action

Opioid-receptor antagonism

Adverse effects

Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema

Pharmacokinetics
Onset of action

1-2 minutes (IV), 2-5 minutes (IM)

Duration of action

30-60 minutes

Metabolism

Hepatic

Elimination half-life

1-1.5 hours

Physical and chemical data
Formula

C19H21NO4

Molar mass

327.380 g/mol

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Naloxone is an opioid-receptor antagonist which is used for the reversal of opioid overdose.

Uses

Contraindications

Absolute contraindications

Precautions

Pharmacology

Pharmacodynamics

Mechanism of action

Adverse effects

Pharmacokinetics

Chemistry and formulation

History

References