Difference between revisions of "Naloxone"
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Chris Rishel (talk | contribs) Tag: 2017 source edit |
Chris Rishel (talk | contribs) Tag: 2017 source edit |
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| mechanism = Opioid-receptor antagonism | | mechanism = Opioid-receptor antagonism | ||
| adverse_effects = Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema | | adverse_effects = Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema | ||
| time_onset = 1-2 minutes (IV) | | time_onset = 1-2 minutes (IV)<br/>2-5 minutes (IM) | ||
| duration = 30-60 minutes | | duration = 30-60 minutes | ||
| metabolism = Hepatic | | metabolism = Hepatic | ||
Revision as of 09:22, 17 February 2021
Naloxone
| Trade names |
Narcan |
|---|---|
 | |
| Clinical data | |
| Uses |
Reversal of opioid agonism |
| Routes of administration |
Intramuscular, Intranasal, Intravenous |
| Dosage |
0.04-0.4 mg IV q2-3min prn |
| Pharmacodynamics | |
| Mechanism of action |
Opioid-receptor antagonism |
| Adverse effects |
Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema |
| Pharmacokinetics | |
| Onset of action |
1-2 minutes (IV) |
| Duration of action |
30-60 minutes |
| Metabolism |
Hepatic |
| Elimination half-life |
1-1.5 hours |
| Physical and chemical data | |
| Formula |
C19H21NO4 |
| Molar mass |
327.380 g/mol |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Naloxone is an opioid-receptor antagonist which is used for the reversal of opioid overdose.
Uses
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
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