Naloxone

Naloxone

Trade names	Narcan
Clinical data
Uses	Reversal of opioid agonism
Routes of administration	Intramuscular, Intranasal, Intravenous
Dosage	Delayed emergence: 20-200 mcg IV q2-3m Opioid overdose: 0.1-2 mg IV/IM/ETT q2-3m
Pharmacodynamics
Mechanism of action	μ-opioid antagonism
Adverse effects	Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema
Pharmacokinetics
Onset of action	1-2 minutes (IV) 2-5 minutes (IM)
Duration of action	30-60 minutes
Metabolism	Hepatic
Elimination half-life	1-1.5 hours
Physical and chemical data
Formula	C19H21NO4
Molar mass	327.380 g/mol
Article quality
Editor rating	In development
User likes	0

Naloxone is an opioid-receptor antagonist which is used for the reversal of opioid overdose.