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• 14:55, 15 March 2022 Olivia Sutton talk contribs created page Local anesthetic systemic toxicity (Created page with " ====== Local Anesthetic Systemic Toxicity (LAST) ====== * More vascular injection sites, dose, the local anesthetic's intrinsic pharmacokinetic properties, and the addition of a vasoactive agent all affect the risk for LAST * CNS toxicity: ** Local anesthetics readily cross the blood brain barrier ** Clinical manifestations: lightheadedness, tinnitus, tongue numbness, metallic taste → CNS excitation (block inhibitory pathways) → CNS depression, seizure → coma * C...") Tag: Visual edit