Difference between revisions of "Naloxone"
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Chris Rishel (talk | contribs) m Tag: 2017 source edit |
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| Line 11: | Line 11: | ||
Opioid overdose: | Opioid overdose: | ||
* 0.1-2 mg IV/IM/ETT q2-3m | * 0.1-2 mg IV/IM/ETT q2-3m | ||
| mechanism = | | mechanism = μ-opioid antagonism | ||
| adverse_effects = Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema | | adverse_effects = Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema | ||
| time_onset = 1-2 minutes (IV)<br/>2-5 minutes (IM) | | time_onset = 1-2 minutes (IV)<br/>2-5 minutes (IM) | ||
Revision as of 02:41, 12 November 2021
Naloxone
| Trade names |
Narcan |
|---|---|
 | |
| Clinical data | |
| Uses |
Reversal of opioid agonism |
| Routes of administration |
Intramuscular, Intranasal, Intravenous |
| Dosage |
Delayed emergence:
Opioid overdose:
|
| Pharmacodynamics | |
| Mechanism of action |
μ-opioid antagonism |
| Adverse effects |
Acute opioid withdrawal, hypotension, arrhythmias, pulmonary edema |
| Pharmacokinetics | |
| Onset of action |
1-2 minutes (IV) |
| Duration of action |
30-60 minutes |
| Metabolism |
Hepatic |
| Elimination half-life |
1-1.5 hours |
| Physical and chemical data | |
| Formula |
C19H21NO4 |
| Molar mass |
327.380 g/mol |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Naloxone is an opioid-receptor antagonist which is used for the reversal of opioid overdose.
Uses
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
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