Difference between revisions of "Ketamine"

Ketamine
Trade names	Ketalar
	Clinical data
Drug class	Sedative hypnotic
Uses	Induction and maintenance of anesthesia, sedation, analgesia
Contraindications	<3 months old; Situations where elevated blood pressure or myocardial oxygen demand would be dangerous; Schizophrenia; Use controversial with elevated ICP or IOP;
Routes of administration	IV, IM, IN, PO, PR
	Dosage
	Pharmacodynamics
Mechanism of action	NMDA antagonism
Adverse effects	Laryngospasm Hypersalivation Emesis Emergence reaction
	Pharmacokinetics
Onset of action	IV: 15-30 seconds; IM: 3-5 minutes;
Duration of action	IV: 5-10 minutes; IM: 12-30 minutes (residual 0.5-2 hours); PO: 1-6+ hours;
Metabolism	Liver (CYP3A4, CYP2B6)
Elimination half-life	2.5-3 hours
Protein binding	23-47%
	Physical and chemical data
Formula	C13H16ClNO
Molar mass	237.73 g/mol
	Article quality
Editor rating	In development
User likes	0

Revision as of 23:12, 29 March 2022

Ketamine is a dissociative anesthetic used for the induction of anesthesia, procedural sedation, and as an analgesic adjunct.

@@ Line 6: / Line 6: @@
 | drug_class_color = sedative_hypnotic
 | uses = Induction and maintenance of anesthesia, sedation, analgesia
-| contraindications =
+| contraindications = * <3 months old
-* <3 months old
 * Situations where elevated blood pressure or myocardial oxygen demand would be dangerous
 * Schizophrenia
 * Use controversial with elevated ICP or IOP
 | routes = IV, IM, IN, PO, PR
-| dosage = Induction of anesthesia:
+| dosage =
-* IV: 1-2 mg/kg
+| dosage_calculation = ketamine
-* IM: 4-6 mg/kg
-* IN: 3-6 mg/kg
-Subdissociative analgesia:
-* IV: 0.1-0.3 mg/kg, then 0.1 mg/kg/hr
 | mechanism = NMDA antagonism
 | adverse_effects = Laryngospasm