Difference between revisions of "Ketamine"

Ketamine
Trade names	Ketalar
	Clinical data
Drug class	Sedative hypnotic
Uses	Induction and maintenance of anesthesia, sedation, analgesia
Contraindications	<3 months old; Situations where elevated blood pressure or myocardial oxygen demand would be dangerous; Schizophrenia; Use controversial with elevated ICP or IOP;
Routes of administration	IV, IM, IN, PO, PR
Dosage	Induction of anesthesia: IV: 1-2 mg/kg; IM: 4-6 mg/kg; IN: 3-6 mg/kg; Subdissociative analgesia: IV: 0.1-0.3 mg/kg, then 0.1 mg/kg/hr;
	Pharmacodynamics
Mechanism of action	NMDA antagonism
Adverse effects	Laryngospasm Hypersalivation Emesis Emergence reaction
	Pharmacokinetics
Onset of action	IV: 15-30 seconds; IM: 3-5 minutes;
Duration of action	IV: 5-10 minutes; IM: 12-30 minutes (residual 0.5-2 hours); PO: 1-6+ hours;
Metabolism	Liver (CYP3A4, CYP2B6)
Elimination half-life	2.5-3 hours
Protein binding	23-47%
	Physical and chemical data
Formula	C13H16ClNO
Molar mass	237.73 g/mol
	Article quality
Editor rating	In development
User likes	0

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Revision as of 10:47, 27 May 2021

Ketamine is a dissociative anesthetic used for the induction of anesthesia, procedural sedation, and as an analgesic adjunct.

Uses

Contraindications

Absolute contraindications

Precautions

Pharmacology

Pharmacodynamics

Mechanism of action

Adverse effects

Pharmacokinetics

Chemistry and formulation

History

References

Top contributors: Stuart van der Greeff, Chris Rishel and Darreon Schwartz

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-Test
+{{Infobox drug reference
+| trade_names = Ketalar
+| image_file = Ketamine.svg
+| image_caption =
+| drug_class = Sedative hypnotic
+| drug_class_color = sedative_hypnotic
+| uses = Induction and maintenance of anesthesia, sedation, analgesia
+| contraindications =
+* <3 months old
+* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous
+* Schizophrenia
+* Use controversial with elevated ICP or IOP
+| routes = IV, IM, IN, PO, PR
+| dosage = Induction of anesthesia:
+* IV: 1-2 mg/kg
+* IM: 4-6 mg/kg
+* IN: 3-6 mg/kg
+Subdissociative analgesia:
+* IV: 0.1-0.3 mg/kg, then 0.1 mg/kg/hr
+| mechanism = NMDA antagonism
+| adverse_effects = Laryngospasm
+Hypersalivation
+Emesis
+Emergence reaction
+| time_onset = * IV: 15-30 seconds
+* IM: 3-5 minutes
+| duration = * IV: 5-10 minutes
+* IM: 12-30 minutes (residual 0.5-2 hours)
+* PO: 1-6+ hours
+| metabolism = Liver (CYP3A4, CYP2B6)
+| halflife_elimination = 2.5-3 hours
+| protein_binding = 23-47%
+| formula = C<sub>13</sub>H<sub>16</sub>ClNO
+| molar_mass = 237.73 g/mol
+}}
-New Line
+'''Ketamine''' is a dissociative anesthetic used for the induction of anesthesia, procedural sedation, and as an analgesic adjunct.
+== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> ==
-Break
+== Contraindications<!-- List contraindications and precautions for use of the drug. --> ==
+=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> ===
+=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> ===
+== Pharmacology ==
+=== Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system --> ===
+==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ====
+==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====
+=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===
+== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==
+== History<!-- Describe the historical development of the drug. --> ==
+== References ==
+[[Category:Drug reference]]