Difference between revisions of "Dexmedetomidine"
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== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> == | == Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> == | ||
ICU, intra-operative, and procedural sedation without respiratory depression or amnestic properties. May decrease opioid requirement, more so due to sedating rather than analgesic effects. | |||
== Contraindications<!-- List contraindications and precautions for use of the drug. --> == | ==Contraindications<!-- List contraindications and precautions for use of the drug. -->== | ||
=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> === | ===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->=== | ||
=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> === | ===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->=== | ||
== Pharmacology == | ==Pharmacology== | ||
=== Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system --> === | ===Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system -->=== | ||
==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ==== | ====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->==== | ||
alpha-2 agonist | alpha-2 agonist | ||
==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ==== | ====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ||
Risk of hypotension and bradycardia, in a dose-dependent manner. Night terrors and transient behavioral effects in children have been reported when used for pre-anesthetic sedation, due to calming effects without amnestic properties. | |||
=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> === | ===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->=== | ||
== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> == | ==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->== | ||
== History<!-- Describe the historical development of the drug. --> == | ==History<!-- Describe the historical development of the drug. -->== | ||
== References == | ==References== | ||
[[Category:Drug reference]] | [[Category:Drug reference]] | ||
[[Category:Sedative hypnotics]] | [[Category:Sedative hypnotics]] | ||
Revision as of 20:29, 3 February 2022
Dexmedetomidine
 | |
| Clinical data | |
| Drug class |
Sedative hypnotic |
|---|---|
| Routes of administration |
IV, IM, IN |
| Pharmacodynamics | |
| Mechanism of action |
Alpha-2 agonism |
| Pharmacokinetics | |
| Physical and chemical data | |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Provide a brief summary of this drug here.
Uses
ICU, intra-operative, and procedural sedation without respiratory depression or amnestic properties. May decrease opioid requirement, more so due to sedating rather than analgesic effects.
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
alpha-2 agonist
Adverse effects
Risk of hypotension and bradycardia, in a dose-dependent manner. Night terrors and transient behavioral effects in children have been reported when used for pre-anesthetic sedation, due to calming effects without amnestic properties.