Difference between revisions of "Fentanyl"

Fentanyl
Trade names	Actiq, Duragesic, Sublimaze
	Clinical data
Drug class	Opioid
Uses	Analgesia
Routes of administration	Buccal, Epidural, Intrathecal, Intravenous, Transdermal
	Dosage
	Pharmacodynamics
Mechanism of action	μ-opioid agonism
	Pharmacokinetics
Onset of action	5 minutes
Duration of action	30-60 minutes
Metabolism	Hepatic (CYP3A4)
Redistribution half-life	6 minutes (initial) 1 hour (slow)
Elimination half-life	16 hours
Protein binding	80-85%
	Physical and chemical data
Formula	5 minutes
Molar mass	336.479 g/mol
	Article quality
Editor rating	In development
User likes	0

VisualWikitext

Latest revision as of 18:31, 1 February 2023

Fentanyl is a synthetic, lipophilic phenylpiperidine opioid agonist used for analgesia. It is highly lipophilic leading to fast passage across the blood-brain barrier with a 6.8 minute onset time. Fentanyl will also rapidly redistribute to adipose and fatty tissue leading to a short duration of action.

Uses

Administration
- IV, IM, transdermal, intranasal, intrathecal, epidural, buccal.

Contraindications

Absolute contraindications

Precautions

Pharmacology

Pharmacodynamics

Mechanism of action

µ-selective opioid receptor
Low affinity: delta & kappa opioid receptors

Adverse effects

Pharmacokinetics

Context Sensitive Half Time
- Infusion or repeated doses lead to prolong duration of action as drug redistributes back from tissue to plasma.

Chemistry and formulation

History

References

Comer SD, Cahill CM. Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment. Neurosci Biobehav Rev. 2019 Nov;106:49-57.

Top contributors: Chris Rishel and Jashvin Patel

@@ Line 23: / Line 23: @@
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-'''Fentanyl''' is an opioid used for analgesia.
+'''Fentanyl''' is a synthetic, lipophilic phenylpiperidine opioid agonist used for analgesia. It is highly lipophilic leading to fast passage across the blood-brain barrier with a 6.8 minute onset time. Fentanyl will also rapidly redistribute to adipose and fatty tissue leading to a short duration of action.
 ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==
+* Administration
+** IV, IM, transdermal, intranasal, intrathecal, epidural, buccal.
 ==Contraindications<!-- List contraindications and precautions for use of the drug. -->==
@@ Line 32: / Line 35: @@
 ===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===
+*
 ==Pharmacology==
@@ Line 38: / Line 43: @@
 ====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====
+* µ-selective opioid receptor
+* Low affinity: delta & kappa opioid receptors
 ====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====
 ===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===
+* Context Sensitive Half Time
+** Infusion or repeated doses lead to prolong duration of action as drug redistributes back from tissue to plasma.
 ==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->==
@@ Line 48: / Line 59: @@
 ==References==
+# Comer SD, Cahill CM. Fentanyl: Receptor pharmacology, abuse potential, and implications for treatment. Neurosci Biobehav Rev. 2019 Nov;106:49-57.
 [[Category:Drug reference]]