Difference between revisions of "Propofol"
From WikiAnesthesia
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| formula = C<sub>12</sub>H<sub>18</sub>O | | formula = C<sub>12</sub>H<sub>18</sub>O | ||
| molar_mass = 178.275 g/mol | | molar_mass = 178.275 g/mol | ||
}}Provide a brief summary of this drug here. | }}Provide a brief summary of this drug here. | ||
==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->== | ||
Revision as of 18:15, 6 February 2021
Propofol
| Trade names |
Diprivan |
|---|---|
 | |
| Clinical data | |
| Drug class |
Sedative hypnotic |
| Uses |
Induction and maintenance of anesthesia, sedation |
| Contraindications |
Egg/soy allergy (controversial) |
| Routes of administration |
Intravenous |
| Dosage |
Induction of anesthesia:
Maintenance of anesthesia:
|
| Pharmacodynamics | |
| Mechanism of action |
GABA agonism |
| Adverse effects |
Hypotension Bradycardia Pain on injection |
| Pharmacokinetics | |
| Onset of action |
15-30 seconds |
| Duration of action |
5-10 minutes |
| Metabolism |
Liver glucuronidation |
| Redistribution half-life |
2-8 minutes (initial) 30-70 minutes (slow) |
| Elimination half-life |
1.5-31 hours |
| Clearance |
1.5-2.2 L/min |
| Protein binding |
95-99% |
| pKa |
11 |
| Volume of distribution |
6-40 L (central) 150-700 L (steady state) |
| Physical and chemical data | |
| Formula |
C12H18O |
| Molar mass |
178.275 g/mol |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Provide a brief summary of this drug here.
Uses
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
References
Top contributors: Chris Rishel and Barrett Larson