Ketorolac

Ketorolac

Trade names	Toradol
Clinical data
Drug class	NSAID
Uses	Post-op pain
Contraindications	Renal disease or injury, peptic ulcer disease, GI bleeding
Routes of administration	IV, IM, oral
Dosage	IV or IM: 30mg once, if needed can repeat q6h up to 120mg daily
Dosage
Ketorolac Adult dosing 10-30 mg IV 0.33-1 mL of 30 mg/mL More information about this dose Weight kglbg Height cmminft Age yrmowk SexFM Indication  Indication: Analgesia Route  Route: Intravenous Preparation  Preparation: 15 mg/mL30 mg/mL A 10 mg dose of ketorolac is as effective for acute pain control as a 15 or 30 mg dose1 Motov S, Yasavolian M, Likourezos A, Pushkar I, Hossain R, Drapkin J, Cohen V, Filk N, Smith A, Huang F, Rockoff B, Homel P, Fromm C. Comparison of Intravenous Ketorolac at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial. Ann Emerg Med. 2017 Aug;70(2):177-184. doi: 10.1016/j.annemergmed.2016.10.014. Epub 2016 Dec 16. PMID: 27993418.
Pharmacodynamics
Mechanism of action	Inhibition of COX (COX-1 > COX-2)
Pharmacokinetics
Onset of action	10-15 minutes
Duration of action	2-4 hours
Physical and chemical data
Article quality
Editor rating	In development
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Ketorolac is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that is frequently used intra-op for management of post-op pain.

Uses

• Post-op pain management

Contraindications

Absolute contraindications

• GFR < 30mL/min

Precautions

• Chronic renal disease
• AKI
• GI bleeding
• Peptic ulcer disease

Pharmacology

Pharmacodynamics

Mechanism of action

• NSAID that inhibits COX
• Of the NSAIDs, most selective for COX-1 inhibition over COX-2

Adverse effects

• COX-1 selectivity increases risk for GI tract irritation and bleeding
• Thromboembolic disease is always a consideration when using NSAIDs, although ketorolac has lower risk for exacerbating thromboembolic disease compared to more COX-2 selective agents like celecoxib

Pharmacokinetics

• Highly protein bound
• Almost completely renally eliminated