Nitric oxide
From WikiAnesthesia
Nitric oxide
| Clinical data | |
| Pharmacodynamics | |
| Pharmacokinetics | |
| Physical and chemical data | |
| Article quality | |
| Editor rating | |
|---|---|
| User likes | 0 |
Nitric oxide (NO) is a naturally occurring endothelial-derived vasodilator that exhibits most of its vasodilatory effects in the pulmonary vasculature.[1] It is frequently indicated for patients with right heart failure and hypoxemia. It exists as a colorless odorless gas, and is administered inhalationally.
Uses
- Pulmonary HTN
- After heart transplant
- Right ventricular failure
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Nitric oxide diffuses to smooth muscle of pulmonary vasculature -> activates soluble guanylate cyclase (sGC) -> converts GTP to cGMP -> activates protein kinase G -> increases Ca2+ reuptake -> decreased calcium decreasing myosin phosphorylation -> relaxation of smooth muscle.
Adverse effects
Pharmacokinetics
Chemistry and formulation
History
Initially discovered in 1987. Won Nobel Prize in Physiology and Medicine in 1998.
References
- ↑ Ichinose, Fumito; Roberts, Jesse D.; Zapol, Warren M. (2004-06-29). "Inhaled Nitric Oxide". Circulation. 109 (25): 3106–3111. doi:10.1161/01.CIR.0000134595.80170.62.
Top contributors: Tony Wang