Difference between revisions of "Excision of pheochromocytoma"
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Pheochromocytoma is a rare neuroendocrine disease of the adrenal gland where catecholamine-secreting tumors cause hypertension. Pheochromocytoma is present in 0.05% - 0.2% of hypertensive individuals, the incidence of the disease presents equally between men and women with a distribution across age groups but peaks in between 40 and 50 years of age. The classic presentation of the disease is a triad of symptoms including headache, palpitations, diaphoresis with a documented clinical sign of hypertension (present in 90% of patients with pheochromocytoma). However, patients can often present with less definitive symptoms such as tremor, anxiety, flushing, weight loss, and hyperglycemia. While the majority of pheochromocytoma emerges from adrenal tumors, roughly 15-20% can be extra-adrenal in etiology. | Pheochromocytoma is a rare neuroendocrine disease of the adrenal gland where catecholamine-secreting tumors cause hypertension. Pheochromocytoma is present in 0.05% - 0.2% of hypertensive individuals, the incidence of the disease presents equally between men and women with a distribution across age groups but peaks in between 40 and 50 years of age. The classic presentation of the disease is a triad of symptoms including headache, palpitations, diaphoresis with a documented clinical sign of hypertension (present in 90% of patients with pheochromocytoma). However, patients can often present with less definitive symptoms such as tremor, anxiety, flushing, weight loss, and hyperglycemia. While the majority of pheochromocytoma emerges from adrenal tumors, roughly 15-20% can be extra-adrenal in etiology. | ||
During the early part of the 20th century, the perioperative mortality of this disease ranged between 26-50%. As surgery is curative in about 90% of presenting cases, the mortality has decreased to roughly 1% in specialized centers. Surgical resection can be approached in a variety of ways: (1) open laparotomy; (2) laparoscopic | During the early part of the 20th century, the perioperative mortality of this disease ranged between 26-50%. As surgery is curative in about 90% of presenting cases, the mortality has decreased to roughly 1% in specialized centers. Surgical resection can be approached in a variety of ways: (1) open laparotomy; (2) laparoscopic transabdominal; and (3) laparoscopic retroperitoneal. Each approach has different indications, advantages and disadvantages, as well as unique line and monitoring choices. | ||
{{Infobox surgical case reference | {{Infobox surgical case reference | ||
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! | ! | ||
!Open Laparotomy | !Open Laparotomy | ||
! | !Transabdominal | ||
Laparoscopic | Laparoscopic | ||
!Retroperitoneal | !Retroperitoneal | ||
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|- | |- | ||
|Surgical time | |Surgical time | ||
| | |4-6 hrs | ||
|3-5 hrs | |3-5 hrs | ||
|1.5 hrs | |1.5 hrs | ||
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|- | |- | ||
|Postoperative disposition | |Postoperative disposition | ||
| | |PACU or ICU | ||
| | |PACU or ICU | ||
|PACU | |PACU | ||
|- | |- | ||
|Pain management | |Pain management | ||
| | |Epidural | ||
| | |Oral and IV pain medications | ||
|Oral pain medications | |Oral pain medications | ||
|- | |- | ||
Revision as of 13:29, 1 May 2021
Pheochromocytoma is a rare neuroendocrine disease of the adrenal gland where catecholamine-secreting tumors cause hypertension. Pheochromocytoma is present in 0.05% - 0.2% of hypertensive individuals, the incidence of the disease presents equally between men and women with a distribution across age groups but peaks in between 40 and 50 years of age. The classic presentation of the disease is a triad of symptoms including headache, palpitations, diaphoresis with a documented clinical sign of hypertension (present in 90% of patients with pheochromocytoma). However, patients can often present with less definitive symptoms such as tremor, anxiety, flushing, weight loss, and hyperglycemia. While the majority of pheochromocytoma emerges from adrenal tumors, roughly 15-20% can be extra-adrenal in etiology.
During the early part of the 20th century, the perioperative mortality of this disease ranged between 26-50%. As surgery is curative in about 90% of presenting cases, the mortality has decreased to roughly 1% in specialized centers. Surgical resection can be approached in a variety of ways: (1) open laparotomy; (2) laparoscopic transabdominal; and (3) laparoscopic retroperitoneal. Each approach has different indications, advantages and disadvantages, as well as unique line and monitoring choices.
| Anesthesia type |
General |
|---|---|
| Airway |
ETT |
| Lines and access |
Arterial line Additional large-bore PIVs +/- Central venous catheter +/- Pulmonary Artery Catheter +/- Epidural catheter (dependant upon approach) |
| Monitors |
Stanford Monitors Invasive blood pressure monitor +/- Central venous catheter +/- Pulmonary Artery Catheter |
| Primary anesthetic considerations | |
| Preoperative |
Preoperative alpha-blockade |
| Intraoperative |
Rapid episodes of extreme hypertension Severe hypotension after adrenal vein ligation Cardiovascular collapse Hyperglycemia Hypovolemia |
| Postoperative |
Residual hypertension Prolonged hypotension (requiring vasopressors) Hyperglycemia/Hypoglycemia |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Preoperative management
Patient evaluation
| System | Considerations |
|---|---|
| Neurologic | |
| Cardiovascular | |
| Respiratory | |
| Gastrointestinal | |
| Hematologic | |
| Renal | |
| Endocrine | |
| Other |
Labs and studies
Operating room setup
Patient preparation and premedication
Regional and neuraxial techniques
Intraoperative management
Monitoring and access
Induction and airway management
Positioning
Maintenance and surgical considerations
Emergence
Postoperative management
Disposition
Pain management
Potential complications
Procedure variants
| Open Laparotomy | Transabdominal
Laparoscopic |
Retroperitoneal
Laparoscopic | |
|---|---|---|---|
| Unique considerations | High Insufflation pressures (20-30mmHg) | ||
| Position | Supine | Lateral | Prone |
| Surgical time | 4-6 hrs | 3-5 hrs | 1.5 hrs |
| EBL | 60-100mL | ||
| Postoperative disposition | PACU or ICU | PACU or ICU | PACU |
| Pain management | Epidural | Oral and IV pain medications | Oral pain medications |
| Potential complications | Subcutaneous emphysema |