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{{Infobox drug reference
{{Infobox drug reference
| trade_names =  
| trade_names = Norcuron
| drug_class = Neuromuscular blocker
| drug_class = Neuromuscular blocker
| drug_class_color = neuromuscular_blocker
| drug_class_color = neuromuscular_blocker
| uses =  
| uses = Tracheal intubation, surgical relaxation, optimizing mechanical ventilation conditions, patients with ARDS
| contraindications =  
| contraindications = Known hypersensitivity
| routes = Intravenous
| routes = Intravenous
| dosage =  
| dosage =  
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| clearance =  
| clearance =  
| halflife_elimination =  
| halflife_elimination =  
| adverse_effects =  
| adverse_effects = Anaphylactic reaction
| metabolism =  
| metabolism = Liver, bile, and renal
| duration =  
| duration = 40
| time_onset =  
| time_onset =  
| dosage_calculation = vecuronium
| dosage_calculation = vecuronium
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}}
}}


Provide a brief summary of this drug here.
Vecuronium is a steroidal intermediate acting non-depolarizing neuromuscular blocking agent used for tracheal intubation and surgical relaxation in patients. It is also used to provide paralysis in patients with acute respiratory distress syndrome in the intensive care unit.  


==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==
==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==
* Optimizing tracheal intubation condition
** Abduction of vocal cords
** Opening of mouth
** Reduction in coughing and gagging
* Provide surgical relaxation
* Optimizing mechanical ventilation conditions
** Reduction in bucking/coughing
** Reduction in breath stacking
* Provide paralysis in patients with acute respiratory distress syndrome in the intensive care unit via continuous infusion early in the course of ARDS for patients with a PaO2/FiO2 less than 150. The proposed mechanism of the beneficial effect is possibly by lowering trans-pulmonary pressure reducing barotrauma.


==Contraindications<!-- List contraindications and precautions for use of the drug. -->==
==Contraindications<!-- List contraindications and precautions for use of the drug. -->==


===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->===
===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->===
* Known hypersensitivity


===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===
===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===
* Prolonged duration of action in patients with cholestasis or cirrhosis
* Use in patients with renal failure


==Pharmacology==
==Pharmacology==


===Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system -->===
===Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system -->===
* Primarily eliminated via hepatic metabolism: 30-40%
* Elimination via bile: 40%
* Elimination via renal: 20-30%
* 3-desacetylvecuronium, 17-desacetylvecuronium and 3,17-desacetylvecuronium metabolites have neuromuscular blocking activity


====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====
====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====
* Competitive antagonism of acetylcholine at the post junctional receptors preventing depolarization of the muscle preventing any movement. Only one molecule of the neuromuscular blocker is needed to prevent activation of the receptor as it competes with acetylcholine at the two binding sites.


====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====
====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====
* Anaphylactic reaction
*Muscle weakness or myopathy due to persistent failure of neuromuscular transmission and immobilization-induced atrophy of diaphragm
*Posttraummatic stress syndrome from awareness during paralysis if sedation is not used adequately.
*Impairment of ventilation-perfusion distribution and decreased right ventricular end-diastolic volume due to abolishment of spontaneous breathing.
*Incomplete reversal of neuromuscular blocking agent leading to respiratory depression


===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===
===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===
* Duration of action after 1 x ED<sub>95</sub> is 40 minutes<ref name=":0">{{Citation|last=Lien|first=Cynthia A.|title=Neuromuscular Blockers and Reversal Drugs|date=2013|url=http://dx.doi.org/10.1016/b978-1-4377-1679-5.00019-3|work=Pharmacology and Physiology for Anesthesia|pages=325–348|publisher=Elsevier|access-date=2023-01-05|last2=Eikermann|first2=Matthias}}</ref>


==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->==
==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->==
* 2-desmethyl derivative of pancuronium<ref name=":0" />
*Supplied as crystalline particles that may be reconstituted with IV fluid<ref name=":1">{{Cite book|last=Nina.|first=Gupta, Anita. Singh-Radcliff,|url=http://worldcat.org/oclc/940638246|title=Pharmacology in anesthesia practice|date=2013|publisher=Oxford University Press|isbn=978-0-19-978267-3|oclc=940638246}}</ref>


==History<!-- Describe the historical development of the drug. -->==
==History<!-- Describe the historical development of the drug. -->==
* First non-depolarizing neuromuscular blocking agent with an intermediate duration of action to be introduced into clinical practice<ref name=":0" />


==References==
==References==
Lien, Cynthia A.; Eikermann, Matthias (2013), "Neuromuscular Blockers and Reversal Drugs", ''Pharmacology and Physiology for Anesthesia'', Elsevier, pp.&nbsp;325–348, retrieved 2023-01-05<ref name=":0" />
Anita Gupta, Nina Singh-Radcliff. ''Pharmacology in Anesthesia Practice''. Oxford University Press; 2013. Accessed January 5, 2023. <nowiki>https://search-ebscohost-com.laneproxy.stanford.edu/login.aspx?direct=true&db=nlebk&AN=603930&site=ehost-live</nowiki><ref name=":1" />


[[Category:Drug reference]]
[[Category:Drug reference]]
[[Category:Neuromuscular blockers]]
[[Category:Neuromuscular blockers]]
[[Category:Nondepolarizing neuromuscular blockers]]
[[Category:Nondepolarizing neuromuscular blockers]]

Latest revision as of 09:10, 5 January 2023

Vecuronium
Trade names

Norcuron

Vecuronium.svg
Clinical data
Drug class

Neuromuscular blocker

Uses

Tracheal intubation, surgical relaxation, optimizing mechanical ventilation conditions, patients with ARDS

Contraindications

Known hypersensitivity

Routes of administration

Intravenous

Dosage
Pharmacodynamics
Mechanism of action

Nicotinic acetylcholine antagonism

Adverse effects

Anaphylactic reaction

Pharmacokinetics
Duration of action

40

Metabolism

Liver, bile, and renal

Physical and chemical data
Article quality
Editor rating
Unrated
User likes
0

Vecuronium is a steroidal intermediate acting non-depolarizing neuromuscular blocking agent used for tracheal intubation and surgical relaxation in patients. It is also used to provide paralysis in patients with acute respiratory distress syndrome in the intensive care unit.

Uses

  • Optimizing tracheal intubation condition
    • Abduction of vocal cords
    • Opening of mouth
    • Reduction in coughing and gagging
  • Provide surgical relaxation
  • Optimizing mechanical ventilation conditions
    • Reduction in bucking/coughing
    • Reduction in breath stacking
  • Provide paralysis in patients with acute respiratory distress syndrome in the intensive care unit via continuous infusion early in the course of ARDS for patients with a PaO2/FiO2 less than 150. The proposed mechanism of the beneficial effect is possibly by lowering trans-pulmonary pressure reducing barotrauma.

Contraindications

Absolute contraindications

  • Known hypersensitivity

Precautions

  • Prolonged duration of action in patients with cholestasis or cirrhosis
  • Use in patients with renal failure

Pharmacology

Pharmacodynamics

  • Primarily eliminated via hepatic metabolism: 30-40%
  • Elimination via bile: 40%
  • Elimination via renal: 20-30%
  • 3-desacetylvecuronium, 17-desacetylvecuronium and 3,17-desacetylvecuronium metabolites have neuromuscular blocking activity

Mechanism of action

  • Competitive antagonism of acetylcholine at the post junctional receptors preventing depolarization of the muscle preventing any movement. Only one molecule of the neuromuscular blocker is needed to prevent activation of the receptor as it competes with acetylcholine at the two binding sites.

Adverse effects

  • Anaphylactic reaction
  • Muscle weakness or myopathy due to persistent failure of neuromuscular transmission and immobilization-induced atrophy of diaphragm
  • Posttraummatic stress syndrome from awareness during paralysis if sedation is not used adequately.
  • Impairment of ventilation-perfusion distribution and decreased right ventricular end-diastolic volume due to abolishment of spontaneous breathing.
  • Incomplete reversal of neuromuscular blocking agent leading to respiratory depression

Pharmacokinetics

  • Duration of action after 1 x ED95 is 40 minutes[1]

Chemistry and formulation

  • 2-desmethyl derivative of pancuronium[1]
  • Supplied as crystalline particles that may be reconstituted with IV fluid[2]

History

  • First non-depolarizing neuromuscular blocking agent with an intermediate duration of action to be introduced into clinical practice[1]

References

Lien, Cynthia A.; Eikermann, Matthias (2013), "Neuromuscular Blockers and Reversal Drugs", Pharmacology and Physiology for Anesthesia, Elsevier, pp. 325–348, retrieved 2023-01-05[1]

Anita Gupta, Nina Singh-Radcliff. Pharmacology in Anesthesia Practice. Oxford University Press; 2013. Accessed January 5, 2023. https://search-ebscohost-com.laneproxy.stanford.edu/login.aspx?direct=true&db=nlebk&AN=603930&site=ehost-live[2]

  1. 1.0 1.1 1.2 1.3 Lien, Cynthia A.; Eikermann, Matthias (2013), "Neuromuscular Blockers and Reversal Drugs", Pharmacology and Physiology for Anesthesia, Elsevier, pp. 325–348, retrieved 2023-01-05
  2. 2.0 2.1 Nina., Gupta, Anita. Singh-Radcliff, (2013). Pharmacology in anesthesia practice. Oxford University Press. ISBN 978-0-19-978267-3. OCLC 940638246.CS1 maint: extra punctuation (link)