View source for Propofol

{{Infobox drug reference
| trade_names = Diprivan
| image_file = Propofol.svg
| image_caption = 
| drug_class = Sedative hypnotic
| drug_class_color = sedative_hypnotic
| uses = Induction and maintenance of anesthesia, sedation
| contraindications = Egg/soy allergy (controversial)
| routes = Intravenous
| dosage = Induction of anesthesia:
* Adult: 1-2.5 mg/kg
* Elderly: 1-1.5 mg/kg
* Pediatric: 2.5-3.5 mg/kg
Maintenance of anesthesia:
* Adult: 100-200 mcg/kg/min
* Elderly: 50-100 mcg/kg/min
* Pediatric: 125-300 mcg/kg/min
| mechanism = GABA agonism
| adverse_effects = Hypotension
Bradycardia
Pain on injection
| time_onset = 15-30 seconds
| duration = 5-10 minutes
| metabolism = Liver glucuronidation
| halflife_redistribution = 2-8 minutes (initial)
30-70 minutes (slow)
| halflife_elimination = 1.5-31 hours
| clearance = 1.5-2.2 L/min
| protein_binding = 95-99%
| pka = 11
| volume_distribution = 6-40 L (central)
150-700 L (steady state)
| formula = C<sub>12</sub>H<sub>18</sub>O
| molar_mass = 178.275 g/mol
}}'''Propofol''' is the most commonly used intravenous anesthetic, used for the induction and maintenance of [[general anesthesia]], sedation of mechanically ventilated adults, and [[procedural sedation]]. 

==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==

* Induction and maintenance of [[general anesthesia]]
* Sedation for mechanical ventilation
* [[Procedural sedation]]
* Treatment of [[status epilepticus]]
* Treatment of nausea and vomiting

==Contraindications<!-- List contraindications and precautions for use of the drug. -->==

===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->===

===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===

==Pharmacology==

===Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system -->===

====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====
Propofol reduces consciousness through GABA<sub>A</sub> receptor agonism and potentiation.

====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====

* Hypotension
* Bradycardia
* Apnea
* Pain on injection
* Propofol infusion syndrome
* Hypertriglyceridemia

===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===

==Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. -->==

==History<!-- Describe the historical development of the drug. -->==

==References==
[[Category:Drug reference]]
[[Category:Pharmacology]]
[[Category:General anesthetics]]
[[Category:Intravenous anesthetics]]
[[Category:Sedative hypnotics]]
[[Category:Antiemetics]]