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Ketamine is a dissociative anesthetic agent used for induction and maintenance of general anesthesia, sedation, and analgesia.


Ketamine stimulates sympathetic tone and typically increases heart rate, blood pressure, and cardiac output.
==Uses, Dosing, & Administration<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==
Give the drug's indications and the doses for each indication. When the drug can be given my mutltiple routes be sure to specify the route of administration. When dosing is by weight be sure to specify total, adjusted, or ideal body weight.
When there are a range of doses it can be helpful to describe how the dose is chosen and/or give a 'typical' dose. When doses are repeated or a drug is given by infusion it can be helpful to describe titration intervals and increments.
======Indication:======
*Route/Administration Dose Unit (weight qualifier) timing
======Induction of anesthesia:======
*IV over 30 to 60 seconds '''0.5 to 2 mg/kg''' (LBW)
**0.5 to 1 mg/kg in patients with shock
*IM '''4 to 6 mg/kg'''
======Maintenance of anesthesia (adjunct to TIVA or inhalational anesthesia)======
*'''0.25 to 0.35 mg/kg''' at incision, followed by continuous infusion '''up to 1 mg/kg/hour'''
===Special Populations===
====Pediatrics====
====Elderly====
====Renal Impairment====
====Hepatic Impairment====
==Contraindications, Warnings, & Interactions<!-- List contraindications and precautions for use of the drug. -->==
===Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. -->===
===Precautions<!-- List precautions for use of the drug. If none, this section may be removed. -->===
===Pregnancy & Breastfeeding<!-- If appropriate, give the drug's safety in pregnancy and for those breastfeeding -->===
===Drug Interactions===
===Disease-Specific Concerns===
==Adverse Effects==
==Pharmacology==
===Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->===
===Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system -->===
===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===
==Further Resources==
You can use this section to provide sources that offer further information that may be of interest to users. Present them as a bulleted list and give a brief description of the resource.
==References==
[[Category:Drug reference]]

Revision as of 04:59, 4 April 2021