Difference between revisions of "Dexmedetomidine"
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====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->==== | ====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->==== | ||
Central α-2 agonist with a 1600:1 affinity for α-2 receptors over α-1 receptors. | |||
====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ====Adverse effects<!-- Describe any potential adverse effects of the drug. -->==== | ||
Revision as of 10:50, 18 July 2022
Dexmedetomidine
 | |
| Clinical data | |
| Drug class |
Sedative hypnotic |
|---|---|
| Routes of administration |
IV, IM, IN |
| Dosage | |
| Pharmacodynamics | |
| Mechanism of action |
Alpha-2 agonism |
| Pharmacokinetics | |
| Physical and chemical data | |
| Article quality | |
| Editor rating | |
| User likes | 0 |
Provide a brief summary of this drug here.
Uses
ICU, intra-operative, and procedural sedation without respiratory depression or amnestic properties. May decrease opioid requirement, more so due to sedating rather than analgesic effects.
Contraindications
Absolute contraindications
Precautions
Pharmacology
Pharmacodynamics
Mechanism of action
Central α-2 agonist with a 1600:1 affinity for α-2 receptors over α-1 receptors.
Adverse effects
Risk of hypotension and bradycardia, in a dose-dependent manner. Night terrors and transient behavioral effects in children have been reported when used for pre-anesthetic sedation, due to calming effects without amnestic properties.