Difference between revisions of "Carotid endarterectomy"

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}}'''Carotid endarterectomy''' ('''CEA''') is a surgical procedure for treating occlusive atherosclerotic disease involving the common and internal carotid arteries. The procedure is more effective than medical management for patients with high grade stenosis (70–99%), symptomatic moderate stenosis (50-69%), or asymptomatic high-grade stenosis (≥ 60%). CEA involves making a longitudinal incision along the anterior border of the sternocleidomastoid muscle to expose the common, internal, and external carotid arteries as well as the carotid sinus. The carotid artery is then opened and the atherosclerotic plaque is removed. Opening of the carotid artery requires occlusion of the proximal common carotid and distal internal and external carotid arteries, which requires adequate collateral flow from the contralateral common carotid artery or placement of an internal shunt between the proximal common carotid and the distal internal carotid arteries. On removal of the atherosclerotic plaque, the media and adventitia of the arteries may be re-approximated or a graft may be used. These grafts are typically synthetic, but vein grafts are occasionally used.  
}}'''Carotid endarterectomy''' ('''CEA''') is a surgical procedure for treating occlusive atherosclerotic disease involving the common and internal carotid arteries. The procedure is more effective than medical management for patients with high grade stenosis (70–99%), symptomatic moderate stenosis (50-69%), or asymptomatic high-grade stenosis (≥ 60%).<ref>{{Cite journal|last=Texakalidis|first=Pavlos|last2=Giannopoulos|first2=Stefanos|last3=Kokkinidis|first3=Damianos G.|last4=Karasavvidis|first4=Theofilos|last5=Rangel-Castilla|first5=Leonardo|last6=Reavey-Cantwell|first6=John|date=2018-12|title=Carotid Artery Endarterectomy Versus Carotid Artery Stenting for Patients with Contralateral Carotid Occlusion: A Systematic Review and Meta-Analysis|url=http://dx.doi.org/10.1016/j.wneu.2018.08.183|journal=World Neurosurgery|volume=120|pages=563–571.e3|doi=10.1016/j.wneu.2018.08.183|issn=1878-8750}}</ref> CEA involves making a longitudinal incision along the anterior border of the sternocleidomastoid muscle to expose the common, internal, and external carotid arteries as well as the carotid sinus. The carotid artery is then opened and the atherosclerotic plaque is removed. Opening of the carotid artery requires occlusion of the proximal common carotid and distal internal and external carotid arteries, which requires adequate collateral flow from the contralateral common carotid artery or placement of an internal shunt between the proximal common carotid and the distal internal carotid arteries. On removal of the atherosclerotic plaque, the media and adventitia of the arteries may be re-approximated or a graft may be used. These grafts are typically synthetic, but vein grafts are occasionally used.


== Preoperative management ==
== Preoperative management ==
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=== Operating room setup <!-- Describe any unique aspects of operating room preparation. Avoid excessively granular information. Use drug classes instead of specific drugs when appropriate. If none, this section may be removed. --> ===
=== Operating room setup <!-- Describe any unique aspects of operating room preparation. Avoid excessively granular information. Use drug classes instead of specific drugs when appropriate. If none, this section may be removed. --> ===
=== Patient preparation and premedication <!-- Describe any unique considerations for patient preparation and premedication. If none, this section may be removed. --> ===
=== Patient preparation and premedication <!-- Describe any unique considerations for patient preparation and premedication. If none, this section may be removed. --> ===
Premedication in CEA may complicate the immediate postoperative evaluation for stroke or TIA. Use of preoperative benzodiazepines and opioids should be limited. If a discussion of the operation and safety steps is inadequate to alleviate the patient's fear, a small dose of midazolam is preferred to opioid premedication.
 
* Premedication in CEA may complicate the immediate postoperative evaluation for stroke or TIA.  
* Use of preoperative benzodiazepines and opioids should be limited.  
* If a discussion of the operation and safety steps is inadequate to alleviate the patient's fear, a small dose of midazolam is preferred to opioid premedication.


=== Regional and neuraxial techniques <!-- Describe any potential regional and/or neuraxial techniques which may be used for this case. If none, this section may be removed. --> ===
=== Regional and neuraxial techniques <!-- Describe any potential regional and/or neuraxial techniques which may be used for this case. If none, this section may be removed. --> ===
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* Superficial cervical plexus blocks + supplemental field blocks by surgeon  
* Superficial cervical plexus blocks + supplemental field blocks by surgeon  
* Deep cervical plexus blocks are now avoided due to concomitant Horner's Syndrome, phrenic nerve block, and recurrent laryngeal nerve injuries  
* Deep cervical plexus blocks are now avoided due to concomitant Horner's Syndrome, phrenic nerve block, and recurrent laryngeal nerve injuries  
* Patients receiving regional anesthesia for CEA have decreased ICU times and may have decreased need for surgical shunts. Regional anesthesia for CEA, however, does not provide cerebral protection afforded by general anesthesia and it makes conversion to GETA more challenging should the need arise.  
* Patients receiving regional anesthesia for CEA have decreased ICU times and may have decreased need for surgical shunts. Regional anesthesia for CEA, however, does not provide cerebral protection afforded by general anesthesia and it makes conversion to GETA more challenging should the need arise.<ref>{{Cite journal|last=Schechter|first=Matthew A.|last2=Shortell|first2=Cynthia K.|last3=Scarborough|first3=John E.|date=2012-09|title=Regional versus general anesthesia for carotid endarterectomy: The American College of Surgeons National Surgical Quality Improvement Program perspective|url=http://dx.doi.org/10.1016/j.surg.2012.05.008|journal=Surgery|volume=152|issue=3|pages=309–314|doi=10.1016/j.surg.2012.05.008|issn=0039-6060}}</ref>


== Intraoperative management ==
== Intraoperative management ==
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* Standard ASA monitors  
* Standard ASA monitors  
* Arterial line allows prompt vasopressor titration in response to changes in blood pressure, particularly if induced-hypertension is being used during carotid clamping.   
* Arterial line is required as it allows prompt vasopressor titration in response to changes in blood pressure, particularly if induced-hypertension is being used during carotid clamping.<ref>{{Citation|last=Norris|first=Edward J.|title=Anesthesia for Vascular Surgery|date=2010|url=http://dx.doi.org/10.1016/b978-0-443-06959-8.00062-5|work=Miller's Anesthesia|pages=1985–2044|publisher=Elsevier|access-date=2021-10-23}}</ref>  
** Invasive blood pressure monitoring is particularly useful during the immediate postoperative period to monitor for cerebral hyperperfusion syndrome.  
** Invasive blood pressure monitoring is particularly useful during the immediate postoperative period to monitor for cerebral hyperperfusion syndrome.


* [[Electroencephalography|EEG monitoring]], [[Somatosensory evoked potentials|somatosensory evoked potentials]] (SSEPs), and [[Motor evoked potentials|motor evoked potentials]] (MEPs) may be used to assess cerebral perfusion.   
* [[Electroencephalography|EEG monitoring]], [[Somatosensory evoked potentials|somatosensory evoked potentials]] (SSEPs), and [[Motor evoked potentials|motor evoked potentials]] (MEPs) may be used to assess cerebral perfusion.   


=== Induction and airway management <!-- Describe the important considerations and general approach to the induction of anesthesia and how the airway is typically managed for this case. --> ===
=== Induction and airway management <!-- Describe the important considerations and general approach to the induction of anesthesia and how the airway is typically managed for this case. --> ===
If general anesthesia is chosen, endotracheal intubation is preferred over placing an LMA. Choice of induction medications is dependent on patient comorbidies, but caution should be used with ketamine as it increases CMRO2 at a time when cerebral blood flow is limited.


For patients undergoing regional anesthesia light sedation with midazolam, fentanyl, propofol, or dexmedetomidine is reasonable. Avoid heavy sedation as patient cooperation may be required for neurologic exam.  
* If general anesthesia is chosen, endotracheal intubation is preferred over placing an LMA. 
* Induction medications are dependent on patient comorbidies, but caution should be used with ketamine as it increases CMRO2 at a time when cerebral blood flow is limited.
* For regional anesthesia, light sedation with midazolam, fentanyl, propofol, or dexmedetomidine is reasonable. Avoid heavy sedation as patient cooperation may be required for neurologic exam.  


=== Positioning <!--  --> ===
=== Positioning <!--  --> ===
Patients are positioned supine with the head turned away from operative site. Beach chair may be used for comfort in awake patients
 
* Patients are positioned supine with the head turned away from operative site. Beach chair may be used for comfort in awake patients
=== Maintenance and surgical considerations <!-- Describe the important considerations and general approach to the maintenance of anesthesia, including potential complications. Be sure to include any steps to the surgical procedure that have anesthetic implications. --> ===
=== Maintenance and surgical considerations <!-- Describe the important considerations and general approach to the maintenance of anesthesia, including potential complications. Be sure to include any steps to the surgical procedure that have anesthetic implications. --> ===
Volatile anesthetics supplemented with opioids for analgesia and neuromuscular blockade is adequate for CEA without electrophysiologic monitoring (EP). For patients receiving EP monitoring, a total IV anesthetic with propofol and remifentanil provides excellent sedation and operating conditions. 


Heparin is required prior to carotid cross-clamping. The ACT goal is 200-250 seconds.  
* Volatile anesthetics supplemented with opioids for analgesia and neuromuscular blockade is adequate for CEA without electrophysiologic monitoring (EP). 
* For patients receiving EP monitoring, a total IV anesthetic with propofol and remifentanil provides excellent sedation and operating conditions. 
* Heparin is required prior to carotid cross-clamping. The ACT goal is 200-250 seconds.
* Carotid cross clamping may induce a severe vagal response with bradycardia and hypotension. Local anesthetic infiltration by the surgeon prior to cross clamping may improve this response. 
* Unclamping can produce a reflex bradycardia and vasodilation effect 


Carotid cross clamping may induce a severe vagal response with bradycardia and hypotension. Local anesthetic infiltration by the surgeon prior to cross clamping may improve this response. 
=== Blood Pressure Maintenance ===


Unclamping can produce a reflex bradycardia and vasodilation effect
* MAPs should be kept at or above the patient's awake MAP. A phenylephrine drip is a good choice because it's pure α-1 activity decreases the risk of arrhythmias.
 
* Wide swings in blood pressure should be expected during CEA.  
=== Blood Pressure Maintenance ===
* Sudden bradycardia may occur with associated hemodynamic instability, so atropine of glycopyrrolate should be available.   
MAPs should be kept at or above the patient's awake MAP. A phenylephrine drip is a good choice because it's pure α-1 activity decreases the risk of arrhythmias. Wide swings in blood pressure should be expected during CEA. Sudden bradycardia may occur with associated hemodynamic instability, so atropine of glycopyrrolate should be available.   


=== Emergence <!-- List and/or describe any important considerations related to the emergence from anesthesia for this case. --> ===
=== Emergence <!-- List and/or describe any important considerations related to the emergence from anesthesia for this case. --> ===

Revision as of 12:18, 23 October 2021

Carotid endarterectomy
Anesthesia type

GETA vs. regional anesthesia

Airway

Endotracheal Tube

Lines and access

PIV x 2 18 ga or larger is adequate

Monitors

Standard monitors, arterial line

Primary anesthetic considerations
Preoperative
Intraoperative
Postoperative
Article quality
Editor rating
Comprehensive
User likes
2

Carotid endarterectomy (CEA) is a surgical procedure for treating occlusive atherosclerotic disease involving the common and internal carotid arteries. The procedure is more effective than medical management for patients with high grade stenosis (70–99%), symptomatic moderate stenosis (50-69%), or asymptomatic high-grade stenosis (≥ 60%).[1] CEA involves making a longitudinal incision along the anterior border of the sternocleidomastoid muscle to expose the common, internal, and external carotid arteries as well as the carotid sinus. The carotid artery is then opened and the atherosclerotic plaque is removed. Opening of the carotid artery requires occlusion of the proximal common carotid and distal internal and external carotid arteries, which requires adequate collateral flow from the contralateral common carotid artery or placement of an internal shunt between the proximal common carotid and the distal internal carotid arteries. On removal of the atherosclerotic plaque, the media and adventitia of the arteries may be re-approximated or a graft may be used. These grafts are typically synthetic, but vein grafts are occasionally used.

Preoperative management

Patient evaluation

System Considerations
Neurologic Evaluate plaque location and adequacy of collateral flow with carotid angiograms prior to surgery
Cardiovascular Preoperative ECG is useful as perioperative MI is the most common major postoperative complication. Uncontrolled hypertension or diabetes, as well as recent MI are reasons to delay the case.
Respiratory ABGs, Spirometry, and CXRs are useful only if otherwise indicated from the H&P
Hematologic Anti-platelet agents (typically aspirin) are typically initiated preoperatively and continued until the day of surgery to prevent perioperative thromboembolic complications.

Labs and studies

Operating room setup

Patient preparation and premedication

  • Premedication in CEA may complicate the immediate postoperative evaluation for stroke or TIA.
  • Use of preoperative benzodiazepines and opioids should be limited.
  • If a discussion of the operation and safety steps is inadequate to alleviate the patient's fear, a small dose of midazolam is preferred to opioid premedication.

Regional and neuraxial techniques

  • Superficial cervical plexus blocks + supplemental field blocks by surgeon
  • Deep cervical plexus blocks are now avoided due to concomitant Horner's Syndrome, phrenic nerve block, and recurrent laryngeal nerve injuries
  • Patients receiving regional anesthesia for CEA have decreased ICU times and may have decreased need for surgical shunts. Regional anesthesia for CEA, however, does not provide cerebral protection afforded by general anesthesia and it makes conversion to GETA more challenging should the need arise.[2]

Intraoperative management

Monitoring and access

  • Standard ASA monitors
  • Arterial line is required as it allows prompt vasopressor titration in response to changes in blood pressure, particularly if induced-hypertension is being used during carotid clamping.[3]
    • Invasive blood pressure monitoring is particularly useful during the immediate postoperative period to monitor for cerebral hyperperfusion syndrome.

Induction and airway management

  • If general anesthesia is chosen, endotracheal intubation is preferred over placing an LMA.
  • Induction medications are dependent on patient comorbidies, but caution should be used with ketamine as it increases CMRO2 at a time when cerebral blood flow is limited.
  • For regional anesthesia, light sedation with midazolam, fentanyl, propofol, or dexmedetomidine is reasonable. Avoid heavy sedation as patient cooperation may be required for neurologic exam.

Positioning

  • Patients are positioned supine with the head turned away from operative site. Beach chair may be used for comfort in awake patients

Maintenance and surgical considerations

  • Volatile anesthetics supplemented with opioids for analgesia and neuromuscular blockade is adequate for CEA without electrophysiologic monitoring (EP).
  • For patients receiving EP monitoring, a total IV anesthetic with propofol and remifentanil provides excellent sedation and operating conditions.
  • Heparin is required prior to carotid cross-clamping. The ACT goal is 200-250 seconds.
  • Carotid cross clamping may induce a severe vagal response with bradycardia and hypotension. Local anesthetic infiltration by the surgeon prior to cross clamping may improve this response.
  • Unclamping can produce a reflex bradycardia and vasodilation effect

Blood Pressure Maintenance

  • MAPs should be kept at or above the patient's awake MAP. A phenylephrine drip is a good choice because it's pure α-1 activity decreases the risk of arrhythmias.
  • Wide swings in blood pressure should be expected during CEA.
  • Sudden bradycardia may occur with associated hemodynamic instability, so atropine of glycopyrrolate should be available.

Emergence

  • Many surgeons prefer to verify neurologic status prior to extubation
  • Use caution to avoid coughing and bucking which can lead to neck hematoma formation, hypertension, and even hemorrhagic stroke during emergence

Postoperative management

Disposition

Pain management

Potential complications

Neurologic deficits may surface after emboli from plaque or shunts or from hypoperfusion during the procedure

Plaque removal during surgery may cause baroreceptor changes causing either hypotension or hypertension requiring vasoactive medications in the recovery unit

Procedure variants

Variant 1 Variant 2
Unique considerations
Position
Surgical time
EBL
Postoperative disposition
Pain management
Potential complications

References

  1. Texakalidis, Pavlos; Giannopoulos, Stefanos; Kokkinidis, Damianos G.; Karasavvidis, Theofilos; Rangel-Castilla, Leonardo; Reavey-Cantwell, John (2018-12). "Carotid Artery Endarterectomy Versus Carotid Artery Stenting for Patients with Contralateral Carotid Occlusion: A Systematic Review and Meta-Analysis". World Neurosurgery. 120: 563–571.e3. doi:10.1016/j.wneu.2018.08.183. ISSN 1878-8750. Check date values in: |date= (help)
  2. Schechter, Matthew A.; Shortell, Cynthia K.; Scarborough, John E. (2012-09). "Regional versus general anesthesia for carotid endarterectomy: The American College of Surgeons National Surgical Quality Improvement Program perspective". Surgery. 152 (3): 309–314. doi:10.1016/j.surg.2012.05.008. ISSN 0039-6060. Check date values in: |date= (help)
  3. Norris, Edward J. (2010), "Anesthesia for Vascular Surgery", Miller's Anesthesia, Elsevier, pp. 1985–2044, retrieved 2021-10-23