Propofol - Revision history

Chris.Rishel: Added embedded dosage calculation

2022-03-30T06:47:01Z

Added embedded dosage calculation

← Older revision		Revision as of 23:47, 29 March 2022
Line 8:		Line 8:
	\| contraindications = Egg/soy allergy (controversial)		\| contraindications = Egg/soy allergy (controversial)
	\| routes = Intravenous		\| routes = Intravenous
	\| dosage = ~~Induction of anesthesia:~~		\| dosage =
	* Adult: 1-2.5 mg/kg		\| dosage_calculation = propofol
	* Elderly: 1-1.5 mg/kg
	* Pediatric: 2.5-3.5 mg/kg
	~~Maintenance of anesthesia:~~
	* Adult: 100-200 mcg/kg/min
	* Elderly: 50-100 mcg/kg/min
	* Pediatric: 125-300 mcg/kg/min
	\| mechanism = GABA<sub>A</sub> agonism		\| mechanism = GABA<sub>A</sub> agonism
	\| adverse_effects = Hypotension		\| adverse_effects = Hypotension

Chris.Rishel at 11:21, 12 November 2021

2021-11-12T11:21:06Z

← Older revision		Revision as of 04:21, 12 November 2021
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	* Elderly: 50-100 mcg/kg/min		* Elderly: 50-100 mcg/kg/min
	* Pediatric: 125-300 mcg/kg/min		* Pediatric: 125-300 mcg/kg/min
	\| mechanism = GABA agonism		\| mechanism = GABA<sub>A</sub> agonism
	\| adverse_effects = Hypotension		\| adverse_effects = Hypotension
	Bradycardia		Bradycardia

Chris.Rishel at 17:10, 18 February 2021

2021-02-18T17:10:29Z

← Older revision		Revision as of 10:10, 18 February 2021
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	==References==		==References==
			[[Category:Drug reference]]
			[[Category:Pharmacology]]
			[[Category:General anesthetics]]
			[[Category:Intravenous anesthetics]]
			[[Category:Sedative hypnotics]]
			[[Category:Antiemetics]]

Chris.Rishel at 13:15, 10 February 2021

2021-02-10T13:15:06Z

← Older revision		Revision as of 06:15, 10 February 2021
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	\| formula = C<sub>12</sub>H<sub>18</sub>O		\| formula = C<sub>12</sub>H<sub>18</sub>O
	\| molar_mass = 178.275 g/mol		\| molar_mass = 178.275 g/mol
	}}~~Provide a brief summary~~ of ~~this drug here~~.		}}'''Propofol''' is the most commonly used intravenous anesthetic, used for the induction and maintenance of [[general anesthesia]], sedation of mechanically ventilated adults, and [[procedural sedation]].

	==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==		==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==

			* Induction and maintenance of [[general anesthesia]]
			* Sedation for mechanical ventilation
			* [[Procedural sedation]]
			* Treatment of [[status epilepticus]]
			* Treatment of nausea and vomiting

	==Contraindications<!-- List contraindications and precautions for use of the drug. -->==		==Contraindications<!-- List contraindications and precautions for use of the drug. -->==
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	====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====		====Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. -->====
			Propofol reduces consciousness through GABA<sub>A</sub> receptor agonism and potentiation.

	====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====		====Adverse effects<!-- Describe any potential adverse effects of the drug. -->====

			* Hypotension
			* Bradycardia
			* Apnea
			* Pain on injection
			* Propofol infusion syndrome
			* Hypertriglyceridemia

	===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===		===Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. -->===

Barrett.Larson at 01:15, 7 February 2021

2021-02-07T01:15:32Z

← Older revision		Revision as of 18:15, 6 February 2021
Line 33:		Line 33:
	\| formula = C<sub>12</sub>H<sub>18</sub>O		\| formula = C<sub>12</sub>H<sub>18</sub>O
	\| molar_mass = 178.275 g/mol		\| molar_mass = 178.275 g/mol
	}}Provide a brief summary of this drug here.		}}Provide a brief summary of this drug here.

	==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==		==Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. -->==

Chris.Rishel at 22:29, 4 February 2021

2021-02-04T22:29:44Z

← Older revision		Revision as of 15:29, 4 February 2021
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	{{Infobox drug reference		{{Infobox drug reference
	\| trade_names = Diprivan		\| trade_names = Diprivan
	\| image_file = Propofol.~~png~~		\| image_file = Propofol.svg
	\| image_caption =		\| image_caption =
	\| drug_class = Sedative hypnotic		\| drug_class = Sedative hypnotic

Chris.Rishel: Created page with "{{Infobox drug reference | trade_names = Diprivan | image_file = Propofol.png | image_caption = | drug_class = Sedative hypnotic | drug_class_color = sedative_hypnotic | uses..."

2021-02-04T22:29:22Z

Created page with "{{Infobox drug reference | trade_names = Diprivan | image_file = Propofol.png | image_caption = | drug_class = Sedative hypnotic | drug_class_color = sedative_hypnotic | uses..."

New page

{{Infobox drug reference
| trade_names = Diprivan
| image_file = Propofol.png
| image_caption =
| drug_class = Sedative hypnotic
| drug_class_color = sedative_hypnotic
| uses = Induction and maintenance of anesthesia, sedation
| contraindications = Egg/soy allergy (controversial)
| routes = Intravenous
| dosage = Induction of anesthesia:
* Adult: 1-2.5 mg/kg
* Elderly: 1-1.5 mg/kg
* Pediatric: 2.5-3.5 mg/kg
Maintenance of anesthesia:
* Adult: 100-200 mcg/kg/min
* Elderly: 50-100 mcg/kg/min
* Pediatric: 125-300 mcg/kg/min
| mechanism = GABA agonism
| adverse_effects = Hypotension
Bradycardia
Pain on injection
| time_onset = 15-30 seconds
| duration = 5-10 minutes
| metabolism = Liver glucuronidation
| halflife_redistribution = 2-8 minutes (initial)
30-70 minutes (slow)
| halflife_elimination = 1.5-31 hours
| clearance = 1.5-2.2 L/min
| protein_binding = 95-99%
| pka = 11
| volume_distribution = 6-40 L (central)
150-700 L (steady state)
| formula = C<sub>12</sub>H<sub>18</sub>O
| molar_mass = 178.275 g/mol
}}Provide a brief summary of this drug here.

==Uses==

==Contraindications==

===Absolute contraindications===

===Precautions===

==Pharmacology==

===Pharmacodynamics===

====Mechanism of action====

====Adverse effects====

===Pharmacokinetics===

==Chemistry and formulation==

==History==

==References==