Ketorolac - Revision history

Chris.Rishel at 06:13, 24 February 2024

2024-02-24T06:13:25Z

← Older revision		Revision as of 23:13, 23 February 2024
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	\| time_onset = 10-15 minutes		\| time_onset = 10-15 minutes
	\| duration = 2-4 hours		\| duration = 2-4 hours
	}}		}}'''Ketorolac''' is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that is frequently used intra-op for management of post-op pain.

	Ketorolac is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that is frequently used intra-op for management of post-op pain.

	== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> ==		== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> ==

	* Post-op pain management		* Post-op pain management

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	=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> ===		=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> ===

	* GFR < 30mL/min		* GFR < 30mL/min

	=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> ===		=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> ===

	* Chronic renal disease		* Chronic renal disease
	* AKI		* AKI
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	==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ====		==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ====

	* NSAID that inhibits COX		* NSAID that inhibits COX
	* Of the NSAIDs, most selective for COX-1 inhibition over COX-2		* Of the NSAIDs, most selective for COX-1 inhibition over COX-2

	==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====		==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====

	* COX-1 selectivity increases risk for GI tract irritation and bleeding		* COX-1 selectivity increases risk for GI tract irritation and bleeding
	* Thromboembolic disease is always a consideration when using NSAIDs, although ketorolac has lower risk for exacerbating thromboembolic disease compared to more COX-2 selective agents like celecoxib		* Thromboembolic disease is always a consideration when using NSAIDs, although ketorolac has lower risk for exacerbating thromboembolic disease compared to more COX-2 selective agents like celecoxib

	=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===		=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===

	* Highly protein bound		* Highly protein bound
	* Almost completely renally eliminated		* Almost completely renally eliminated

Seanmliu: Updated blank article

2024-02-14T20:16:47Z

Updated blank article

← Older revision		Revision as of 13:16, 14 February 2024
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	{{Infobox drug reference		{{Infobox drug reference
	\| trade_names =		\| trade_names = Toradol
	\| drug_class =		\| drug_class = NSAID
	\| drug_class_color =		\| drug_class_color =
	\| uses =		\| uses = Post-op pain
	\| contraindications =		\| contraindications = Renal disease or injury, peptic ulcer disease, GI bleeding
	\| routes =		\| routes = IV, IM, oral
	\| dosage =		\| dosage = IV or IM: 30mg once, if needed can repeat q6h up to 120mg daily
	\| dosage_calculation = ketorolac		\| dosage_calculation = ketorolac
			\| mechanism = Inhibition of COX (COX-1 > COX-2)
			\| time_onset = 10-15 minutes
			\| duration = 2-4 hours
	}}		}}

	~~Provide~~ a ~~brief summary~~ of ~~this drug here~~.		Ketorolac is a Non-Steroidal Anti-Inflammatory Drug (NSAID) that is frequently used intra-op for management of post-op pain.

	== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> ==		== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> ==

			* Post-op pain management

	== Contraindications<!-- List contraindications and precautions for use of the drug. --> ==		== Contraindications<!-- List contraindications and precautions for use of the drug. --> ==

	=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> ===		=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> ===

			* GFR < 30mL/min

	=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> ===		=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> ===

			* Chronic renal disease
			* AKI
			* GI bleeding
			* Peptic ulcer disease

	== Pharmacology ==		== Pharmacology ==
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	==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ====		==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ====

			* NSAID that inhibits COX
			* Of the NSAIDs, most selective for COX-1 inhibition over COX-2

	==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====		==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====

			* COX-1 selectivity increases risk for GI tract irritation and bleeding
			* Thromboembolic disease is always a consideration when using NSAIDs, although ketorolac has lower risk for exacerbating thromboembolic disease compared to more COX-2 selective agents like celecoxib

	=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===		=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===

			* Highly protein bound
			* Almost completely renally eliminated

	== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==		== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==
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	== References ==		== References ==
			<ref>Toda C, Naguib M. Peripherally acting analgesics. In: Flood P, Rathmell JP, and Urman RD (eds). Stoelting’s Pharmacology & Physiology in Anesthetic Practice. Sixth edition. Philadelphia, Pennsylvania; Wolters Kluwer; 2022: 257-65.</ref><ref>{{Cite web\|title=Nonsteroidal Anti-inflammatory Drugs\|url=https://www.openanesthesia.org/keywords/nonsteroidal-anti-inflammatory-drugs/\|url-status=live}}</ref><ref>Colvin L. Physiology and pharmacology of pain. In: Thompson, JP, Moppett IK, and Wiles M (eds). Smith and Aitkenhead’s Textbook of Anaesthesia. 7th ed. Edinburgh; Elsevier; 2019: 99-120.</ref><ref>Aronson JK. Non-steroidal anti-inflammatory drugs. In: Aronson, JK. Meyler’s Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. Sixteenth edition. Amsterdam, Netherlands; Elsevier; 2016: 236-72.</ref><ref>Hurley R, Elkassabany NM, Wu CL. Acute postoperative pain. In: Miller’s Anesthesia. 9th ed. Philadelphia; Elsevier; 2020:2620-22.</ref><ref>{{Citation\|last=Mahmoodi\|first=Ahmad N.\|title=Ketorolac\|date=2024\|url=http://www.ncbi.nlm.nih.gov/books/NBK545172/\|work=StatPearls\|place=Treasure Island (FL)\|publisher=StatPearls Publishing\|pmid=31424756\|access-date=2024-02-14\|last2=Kim\|first2=Peggy Y.}}</ref><ref>{{Cite journal\|last=Buckley\|first=Micaela M.-T.\|last2=Brogden\|first2=Rex N.\|date=1990-01-01\|title=Ketorolac\|url=https://doi.org/10.2165/00003495-199039010-00008\|journal=Drugs\|language=en\|volume=39\|issue=1\|pages=86–109\|doi=10.2165/00003495-199039010-00008\|issn=1179-1950}}</ref>
	[[Category:Drug reference]]		[[Category:Drug reference]]

Chris.Rishel: Added embedded dosage calculation

2022-03-30T08:05:21Z

Added embedded dosage calculation

← Older revision		Revision as of 01:05, 30 March 2022
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	\| routes =		\| routes =
	\| dosage =		\| dosage =
			\| dosage_calculation = ketorolac
	}}		}}

Oliviamsutton: Created page with "{{Infobox drug reference | trade_names = | drug_class = | drug_class_color = | uses = | contraindications = | routes = | dosage = }} Provide a brief summary of this dr..."

2021-11-10T17:28:21Z

Created page with "{{Infobox drug reference | trade_names = | drug_class = | drug_class_color = | uses = | contraindications = | routes = | dosage = }} Provide a brief summary of this dr..."

New page

{{Infobox drug reference
| trade_names =
| drug_class =
| drug_class_color =
| uses =
| contraindications =
| routes =
| dosage =
}}

Provide a brief summary of this drug here.

== Uses ==

== Contraindications ==

=== Absolute contraindications ===

=== Precautions ===

== Pharmacology ==

=== Pharmacodynamics ===

==== Mechanism of action ====

==== Adverse effects ====

=== Pharmacokinetics ===

== Chemistry and formulation ==

== History ==

== References ==

[[Category:Drug reference]]