Ketamine - Revision history

Darreonschwartz: added pharmacokinetic data

2022-07-15T00:50:10Z

added pharmacokinetic data

← Older revision		Revision as of 17:50, 14 July 2022
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	* Use controversial with elevated ICP or IOP		* Use controversial with elevated ICP or IOP
	\| routes = IV, IM, IN, PO, PR		\| routes = IV, IM, IN, PO, PR
	\| dosage =		\| dosage = Induction of general anesthesia: 0.5-2 mg/kg IV
	\| dosage_calculation = ketamine		\| dosage_calculation = ketamine
	\| mechanism = NMDA antagonism		\| mechanism = NMDA-receptor antagonism
	\| adverse_effects = Laryngospasm		\| adverse_effects = Laryngospasm
	Hypersalivation		Hypersalivation
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	* IM: 12-30 minutes (residual 0.5-2 hours)		* IM: 12-30 minutes (residual 0.5-2 hours)
	* PO: 1-6+ hours		* PO: 1-6+ hours
			*Context-sensitive half-time: 40-55 minutes after 8 hours of continuous infusion
	\| metabolism = Liver (CYP3A4, CYP2B6)		\| metabolism = Liver (CYP3A4, CYP2B6)
	\| halflife_elimination = 2.5-3 hours		\| halflife_elimination = 2.5-3 hours
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	=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===		=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===
			Metabolized by hepatic microsomal enzymes to norketamine via ''N''-demethylation. Norketamine is then metabolized to hydroxynorketamine. Ultimately, hydroxynorketamine undergoes glucuronide conjugation and is excreted in the urine.

			Norketamine has 33% of the potency of ketamine

			The plasma disappearance of ketamine is traditionally described by a two-compartment model.

			Elimination half-life: 2.5-2.8 hr

			Clearance: 12-17 mL/kg/min

			Vd at steady state: 3.1 L/kg

	== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==		== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==
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	== References ==		== References ==
			Kamp J, Olofsen E, Henthorn TK, van Velzen M, Niesters M, Dahan A; Ketamine Pharmacokinetic Study Group. Ketamine Pharmacokinetics. Anesthesiology. 2020 Dec 1;133(6):1192-1213. doi: 10.1097/ALN.0000000000003577. PMID: 32997732.

			Miller, Ronald D. Miller's Anesthesia. 7th ed. Philadelphia, PA: Churchill Livingstone/Elsevier, 2010.
	[[Category:Drug reference]]		[[Category:Drug reference]]
	[[Category:General anesthetics]]		[[Category:General anesthetics]]

Chris.Rishel: Added embedded dosage calculation

2022-03-30T07:12:35Z

Added embedded dosage calculation

← Older revision		Revision as of 00:12, 30 March 2022
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	\| drug_class_color = sedative_hypnotic		\| drug_class_color = sedative_hypnotic
	\| uses = Induction and maintenance of anesthesia, sedation, analgesia		\| uses = Induction and maintenance of anesthesia, sedation, analgesia
	\| contraindications =		\| contraindications = * <3 months old
	* <3 months old
	* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous		* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous
	* Schizophrenia		* Schizophrenia
	* Use controversial with elevated ICP or IOP		* Use controversial with elevated ICP or IOP
	\| routes = IV, IM, IN, PO, PR		\| routes = IV, IM, IN, PO, PR
	\| dosage = ~~Induction of anesthesia:~~		\| dosage =
	* IV: 1-2 mg/kg		\| dosage_calculation = ketamine
	* IM: 4-6 mg/kg
	* IN: 3-6 mg/kg
	~~Subdissociative analgesia:~~
	* IV: 0.1-0.3 mg/kg, then 0.1 mg/kg/hr
	\| mechanism = NMDA antagonism		\| mechanism = NMDA antagonism
	\| adverse_effects = Laryngospasm		\| adverse_effects = Laryngospasm

Chris.Rishel at 11:51, 12 November 2021

2021-11-12T11:51:46Z

← Older revision		Revision as of 04:51, 12 November 2021
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	[[Category:Intravenous anesthetics]]		[[Category:Intravenous anesthetics]]
	[[Category:Sedative hypnotics]]		[[Category:Sedative hypnotics]]
			[[Category:NMDA antagonists]]

Chris.Rishel at 11:27, 12 November 2021

2021-11-12T11:27:59Z

← Older revision		Revision as of 04:27, 12 November 2021
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	[[Category:General anesthetics]]		[[Category:General anesthetics]]
	[[Category:Intravenous anesthetics]]		[[Category:Intravenous anesthetics]]
			[[Category:Sedative hypnotics]]

Chris.Rishel at 11:23, 12 November 2021

2021-11-12T11:23:19Z

← Older revision		Revision as of 04:23, 12 November 2021
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	[[Category:Drug reference]]		[[Category:Drug reference]]
			[[Category:General anesthetics]]
			[[Category:Intravenous anesthetics]]

Chris.Rishel at 18:48, 27 May 2021

2021-05-27T18:48:05Z

← Older revision		Revision as of 11:48, 27 May 2021
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	\| drug_class_color = sedative_hypnotic		\| drug_class_color = sedative_hypnotic
	\| uses = Induction and maintenance of anesthesia, sedation, analgesia		\| uses = Induction and maintenance of anesthesia, sedation, analgesia
	\| contraindications = _		\| contraindications =
	* <3 months old		* <3 months old
	* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous		* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous

Chris.Rishel at 18:47, 27 May 2021

2021-05-27T18:47:46Z

← Older revision		Revision as of 11:47, 27 May 2021
Line 6:		Line 6:
	\| drug_class_color = sedative_hypnotic		\| drug_class_color = sedative_hypnotic
	\| uses = Induction and maintenance of anesthesia, sedation, analgesia		\| uses = Induction and maintenance of anesthesia, sedation, analgesia
	\| contraindications =		\| contraindications = _

	* <3 months old		* <3 months old
	* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous		* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous

Chris.Rishel at 18:47, 27 May 2021

2021-05-27T18:47:28Z

← Older revision		Revision as of 11:47, 27 May 2021
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	\| uses = Induction and maintenance of anesthesia, sedation, analgesia		\| uses = Induction and maintenance of anesthesia, sedation, analgesia
	\| contraindications =		\| contraindications =

	* <3 months old		* <3 months old
	* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous		* Situations where elevated blood pressure or myocardial oxygen demand would be dangerous

Chris.Rishel at 18:47, 27 May 2021

2021-05-27T18:47:02Z

@@ Line 1: / Line 1: @@
-Test
+{{Infobox drug reference
-New Line
+'''Ketamine''' is a dissociative anesthetic used for the induction of anesthesia, procedural sedation, and as an analgesic adjunct.
-Break
+== Contraindications<!-- List contraindications and precautions for use of the drug. --> ==

Svdg at 15:23, 18 April 2021

2021-04-18T15:23:09Z

← Older revision		Revision as of 08:23, 18 April 2021
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	Test		Test

	New Line		New Line