https://wikianesthesia.org/w/index.php?action=history&feed=atom&title=BupivacaineBupivacaine - Revision history2026-04-18T08:00:54ZRevision history for this page on the wikiMediaWiki 1.37.1https://wikianesthesia.org/w/index.php?title=Bupivacaine&diff=2950&oldid=prevOliviamsutton: Started article, filled out summary table2021-09-07T03:26:06Z<p>Started article, filled out summary table</p>
<p><b>New page</b></p><div>{{Infobox drug reference<br />
| trade_names = Marcaine<br />
| drug_class = Local Anesthetic<br />
| drug_class_color = <br />
| uses = Regional anesthesia, neuraxial anesthesia<br />
| contraindications = Allergy (rare), bier block (due to risk of tourniquet failure and systemic drug absorption causing cardiac arrest)<br />
| routes = Intrathecal, epidural, peripheral nerve block, local infiltration<br />
| dosage = Maximum dose: 2-2.5mg/kg, not to exceed 175mg per dose or 400mg/24h<br />
Spinal anesthesia: commonly 7.5-12mg of 0.75% bupivacaine for C-section under spinal<br />
| mechanism = Sodium channel blockade<br />
| adverse_effects = Cardiotoxicity, LAST<br />
| time_onset = Within 15 mins<br />
| duration = 2-8h<br />
| metabolism = Liver<br />
| halflife_redistribution = <br />
| halflife_elimination = approx 3h<br />
| clearance = <br />
| protein_binding = 95%<br />
}}<br />
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== Uses<!-- Describe uses of the drug. If appropriate, add subsections for each indication. --> ==<br />
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== Contraindications<!-- List contraindications and precautions for use of the drug. --> ==<br />
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=== Absolute contraindications<!-- List absolute contraindications for use of the drug. If none, this section may be removed. --> ===<br />
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=== Precautions<!-- List precautions for use of the drug. If none, this section may be removed. --> ===<br />
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== Pharmacology ==<br />
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=== Pharmacodynamics<!-- Describe the effects of the drug on the body. If appropriate, add subsections by organ system --> ===<br />
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==== Mechanism of action<!-- Describe the mechanism of action for the primary uses of the drug. --> ====<br />
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==== Adverse effects<!-- Describe any potential adverse effects of the drug. --> ====<br />
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=== Pharmacokinetics<!-- Describe the pharmacokinetics of the drug. --> ===<br />
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== Chemistry and formulation<!-- Describe the chemistry and formulation of the drug. --> ==<br />
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== History<!-- Describe the historical development of the drug. --> ==<br />
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== References ==<br />
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[[Category:Drug reference]]</div>Oliviamsutton