Amniotic fluid embolism - Revision history

Oliviamsutton at 20:38, 24 October 2022

2022-10-24T20:38:06Z

← Older revision		Revision as of 13:38, 24 October 2022
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	An amniotic fluid embolism (AFE) is a rare but serious condition with high morbidity and mortality. It is characterized by cardiopulmonary collapse and disseminated intravascular coagulation (DIC). It is the second-leading cause of peripartum maternal death in the US and number one cause of peripartum cardiac arrest. <ref>{{Citation\|last=Haftel\|first=Anthony\|title=Amniotic Fluid Embolism\|date=2022\|url=http://www.ncbi.nlm.nih.gov/books/NBK559107/\|work=StatPearls\|place=Treasure Island (FL)\|publisher=StatPearls Publishing\|pmid=32644533\|access-date=2022-10-20\|last2=Chowdhury\|first2=Yuvraj S.}}</ref>		An amniotic fluid embolism (AFE) is a rare but serious condition with high morbidity and mortality. It is characterized by cardiopulmonary collapse and disseminated intravascular coagulation (DIC). It is the second-leading cause of peripartum maternal death in the US and number one cause of peripartum cardiac arrest. <ref>{{Citation\|last=Haftel\|first=Anthony\|title=Amniotic Fluid Embolism\|date=2022\|url=http://www.ncbi.nlm.nih.gov/books/NBK559107/\|work=StatPearls\|place=Treasure Island (FL)\|publisher=StatPearls Publishing\|pmid=32644533\|access-date=2022-10-20\|last2=Chowdhury\|first2=Yuvraj S.}}</ref>

	~~== Anesthetic implications<!-- Briefly summarize the anesthetic implications of this comorbidity. --> ==~~

	~~=== Preoperative optimization<!-- Describe how this comorbidity may influence preoperative evaluation and optimization of patients. --> ===~~

	~~=== Intraoperative management<!-- Describe how this comorbidity may influence intraoperative management. --> ===~~

	~~=== Postoperative management<!-- Describe how this comorbidity may influence postoperative management. --> ===~~

	== Risk Factors<!-- List and briefly describe any procedures which may be performed specifically to treat this comorbidity or its sequelae. If none, this section may be removed. -->==		== Risk Factors<!-- List and briefly describe any procedures which may be performed specifically to treat this comorbidity or its sequelae. If none, this section may be removed. -->==
	Risk factors for the development of AFE are advanced maternal age, multiparity, male fetuses, and trauma. Induction of labor has also been found to increase risk for AFE.		Risk factors for the development of AFE are advanced maternal age, multiparity, male fetuses, and trauma. Induction of labor has also been found to increase risk for AFE.
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	Normally, pregnancies are procoagulant, to begin with, and the introduction of amniotic fluid and fetal elements trigger inflammatory mediators activating the coagulation cascade and fibrinolytic systems resulting in DIC.		Normally, pregnancies are procoagulant, to begin with, and the introduction of amniotic fluid and fetal elements trigger inflammatory mediators activating the coagulation cascade and fibrinolytic systems resulting in DIC.

	~~== Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. --> ==~~

	== Diagnosis<!-- Describe how this comorbidity is diagnosed. --> ==		== Diagnosis<!-- Describe how this comorbidity is diagnosed. --> ==
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	For the mother, this includes securing the airway, effective ventilation, pressors as appropriate, and fluid management. After intubation, large bore intravascular access should be obtained for resuscitation.		For the mother, this includes securing the airway, effective ventilation, pressors as appropriate, and fluid management. After intubation, large bore intravascular access should be obtained for resuscitation.

	~~== Epidemiology<!-- Describe the epidemiology of this comorbidity --> ==~~

	== References ==		== References ==

	[[Category:Comorbidities]]		[[Category:Comorbidities]]

Oliviamsutton at 20:50, 20 October 2022

2022-10-20T20:50:15Z

← Older revision		Revision as of 13:50, 20 October 2022
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	# No fever		# No fever

	== ~~Treatment~~<!-- Summarize the treatment of this comorbidity. Add subsections as needed. --> ==		== Management<!-- Summarize the treatment of this comorbidity. Add subsections as needed. -->==
			The cornerstone of AFE management is prompt cardiopulmonary resuscitation of the mother with rapid evacuation of the fetus.

	~~=== Medication<!-- Describe medications used to manage~~ this ~~comorbidity~~. ~~--> ===~~		For the mother, this includes securing the airway, effective ventilation, pressors as appropriate, and fluid management. After intubation, large bore intravascular access should be obtained for resuscitation.

	~~=== Surgery<!-- Describe surgical procedures used to treat this comorbidity~~. ~~--> ===~~

	~~=== Prognosis<!-- Describe the prognosis of this comorbidity --> ===~~

	== Epidemiology<!-- Describe the epidemiology of this comorbidity --> ==		== Epidemiology<!-- Describe the epidemiology of this comorbidity --> ==

Oliviamsutton: added info

2022-10-20T20:47:48Z

added info

← Older revision		Revision as of 13:47, 20 October 2022
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	== Risk Factors<!-- List and briefly describe any procedures which may be performed specifically to treat this comorbidity or its sequelae. If none, this section may be removed. -->==		== Risk Factors<!-- List and briefly describe any procedures which may be performed specifically to treat this comorbidity or its sequelae. If none, this section may be removed. -->==
	Risk factors for the development of AFE are advanced maternal age, multiparity, male fetuses, and trauma.		Risk factors for the development of AFE are advanced maternal age, multiparity, male fetuses, and trauma. Induction of labor has also been found to increase risk for AFE.

	== Pathophysiology<!-- Describe the pathophysiology of this comorbidity. Add subsections as needed. --> ==		== Pathophysiology<!-- Describe the pathophysiology of this comorbidity. Add subsections as needed. --> ==
	AFE is poorly understood.		AFE is poorly understood. It is thought to originate from a disruption of the placenta-amniotic interface with the subsequent entry of amniotic fluid and fetal elements (such as hair, meconium, squama, and mucin) into the maternal circulation. Upon entering the pulmonary tree, intense pulmonary vasoconstriction occurs. This may be associated with concomitant bronchoconstriction. The hemodynamic result is acute pulmonary arterial obstruction, dilatation of the right ventricle and the right atrium, and significant tricuspid regurgitation. The right ventricular enlargement causes the intraventricular septum to bow into the left ventricle creating obstruction and systolic dysfunction, further raising pulmonary artery pressure and decreasing cardiac output. Hypoxemia and hypotension lead to sudden cardiovascular collapse.

			Normally, pregnancies are procoagulant, to begin with, and the introduction of amniotic fluid and fetal elements trigger inflammatory mediators activating the coagulation cascade and fibrinolytic systems resulting in DIC.

	== Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. --> ==		== Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. --> ==

	== Diagnosis<!-- Describe how this comorbidity is diagnosed. --> ==		== Diagnosis<!-- Describe how this comorbidity is diagnosed. --> ==
			The American Society for Maternal-Fetal Medicine, after a consensus symposium has created its criteria for AFE, which require the following:

			# Sudden cardiopulmonary collapse, or hypotension (systolic blood pressure less than 90 mmHg) with hypoxia (SpO2 less than 90%)
			# DIC, according to the international society on thrombosis and hemostasis (ISTH) definition
			# Symptomatology either during labor or during placental delivery (or up to 30 minutes later)
			# No fever

	== Treatment<!-- Summarize the treatment of this comorbidity. Add subsections as needed. --> ==		== Treatment<!-- Summarize the treatment of this comorbidity. Add subsections as needed. --> ==

Oliviamsutton at 20:43, 20 October 2022

2022-10-20T20:43:08Z

← Older revision		Revision as of 13:43, 20 October 2022
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	}}		}}

	An amniotic fluid embolism is a rare but serious condition with high morbidity and mortality.		An amniotic fluid embolism (AFE) is a rare but serious condition with high morbidity and mortality. It is characterized by cardiopulmonary collapse and disseminated intravascular coagulation (DIC). It is the second-leading cause of peripartum maternal death in the US and number one cause of peripartum cardiac arrest. <ref>{{Citation\|last=Haftel\|first=Anthony\|title=Amniotic Fluid Embolism\|date=2022\|url=http://www.ncbi.nlm.nih.gov/books/NBK559107/\|work=StatPearls\|place=Treasure Island (FL)\|publisher=StatPearls Publishing\|pmid=32644533\|access-date=2022-10-20\|last2=Chowdhury\|first2=Yuvraj S.}}</ref>

	== Anesthetic implications<!-- Briefly summarize the anesthetic implications of this comorbidity. --> ==		== Anesthetic implications<!-- Briefly summarize the anesthetic implications of this comorbidity. --> ==
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	=== Postoperative management<!-- Describe how this comorbidity may influence postoperative management. --> ===		=== Postoperative management<!-- Describe how this comorbidity may influence postoperative management. --> ===

	== ~~Related surgical procedures~~<!-- List and briefly describe any procedures which may be performed specifically to treat this comorbidity or its sequelae. If none, this section may be removed. --> ==		== Risk Factors<!-- List and briefly describe any procedures which may be performed specifically to treat this comorbidity or its sequelae. If none, this section may be removed. -->==
			Risk factors for the development of AFE are advanced maternal age, multiparity, male fetuses, and trauma.

	== Pathophysiology<!-- Describe the pathophysiology of this comorbidity. Add subsections as needed. --> ==		== Pathophysiology<!-- Describe the pathophysiology of this comorbidity. Add subsections as needed. --> ==
			AFE is poorly understood.

	== Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. --> ==		== Signs and symptoms<!-- Describe the signs and symptoms of this comorbidity. --> ==

Oliviamsutton: started

2022-10-20T20:39:52Z

started

New page

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An amniotic fluid embolism is a rare but serious condition with high morbidity and mortality.

== Anesthetic implications ==

=== Preoperative optimization ===

=== Intraoperative management ===

=== Postoperative management ===

== Related surgical procedures ==

== Pathophysiology ==

== Signs and symptoms ==

== Diagnosis ==

== Treatment ==

=== Medication ===

=== Surgery ===

=== Prognosis ===

== Epidemiology ==

== References ==

[[Category:Comorbidities]]